[18a-Z22-1~11] 12.7 Biomedical Engineering and Biochips

▼ [18a-Z22-4] Effect of Light Emission on Recording Electrodes of Opto-Neural Probe with Upconversion Nanoparticles

〇(M2)Fen Yang¹, Shota Urayama², Haruki Nagasaki¹, Hisashi Kino³, Takafumi Fukushima^1,2, Tetsu Tanaka^1,2 (1.Tohoku Univ. Grad. Sch. of Eng., 2.Tohoku Univ. Grad. Sch. of Biomedical Eng., 3.Tohoku Univ. FRIS)

Keywords:neural probe, microelectrodes, optogenetics

Optical stimulation has been widely used in neuroscience, especially in optogenetics, to induce both inhibition and excitation effects on neurons. Recently, upconversion nanoparticles (UCNP) have attracted much attention as optical stimulus material in optogenetics. Typical UCNP consists of ytterbium and erbium and can emit visible light when irradiated by near-infrared (NIR) light. In our previous work, we developed a wireless opto-neural probe with UCNP light emitter. Then, we fabricated an opto-neural probe with UCNP light emitter and neural recording microelectrodes to realize simultaneously optical stimulation and electrical recording. In this study, we evaluated the effect of the light emission from UCNP on Au electrodes through the electrochemical analysis.