[19p-Z04-1~12] 3.4 Biomedical optics

[19p-Z04-11] Signal-Difference Extraction for Selective Detection of Two-Photon Photoacoustic Signals

〇Takashi Kaneko¹, Seiji Maehara², Syujiro Hamano², Eiji Takahashi¹, Yoshihisa Yamaoka¹ (1.Saga Univ., 2.Terasaki Electric)

Keywords:photoacoustic, two-photon photoacoustic

Two-photon photoacoustic microscopy is used to diagnose non-invasive depth of melanoma. The problem with this microscope is that even in a minute space where two-photon absorption occurs, the spatial resolution is reduced by the one-photon photoacoustic wave. In order to solve this problem, we proposed a method for selectively detecting two-photon photoacoustic waves by changing the optical pulse energy and removing one photoacoustic wave, and verified the principle.