[21p-P01-1~11] 3.1 Basic optics and frontier of optics (merged with formerly 3.2 Equipment optics and materials)

[21p-P01-7] Formation of ultralong liposome tubes by a laser-induced microbubble

〇(M1)Akemi Noguchi¹, Chiaki Kojima¹, Ken-ichi Yuyama¹, Nobuaki Oyamada³, Kei Murakoshi³, Tatsuya Shoji², Yasuyuki Tsuboi¹ (1.Osaka Metropolitan Univ., 2.Kanagawa Univ., 3.Hokkaido Univ.)

Keywords:Soft Matter, Optical Manipulation, Membrane Fusion

The technology of material conversion using a laser beam in a liquid is currently attracting a great deal of attention. In this study, we focused on a soft material used as the simplest cellular model: liposomes. We irradiated a near-infrared laser beam(λ = 808 nm) onto a plasmonic substrate in aqueous solutions of liposome (diameter ~ 200 nm). A microbubble was generated at the focal point on the plasmon substrate immediately after the laser irradiation. Accordingly, liposomes were fused under the microbubble, forming ultralong liposome tubes with a maximum length of more than 30 μm (Kojima et al., ACS Omega, 2022). We succeeded in direct observation of this phenomenon. This is a novel phenomenon that has never been reported before. The phenomenon would be caused by a steep temperature gradient and pressure rise around the bubble by laser irradiation. Based on the phenomenon, we will develop a new technique for membrane fusion.