[25p-E105-1~14] 8.4 Plasma life sciences

[25p-E105-1] Change in permeation characteristics of reactive oxygen species through a biological membrane by electric field and charge

〇Yuta Iwata¹, Shota Yamauchi¹, Ippei Yagi¹, Kosuke Tachibana², Akinoro Oda³, Takehiko Sato⁴, Satoshi Uchida¹ (1.Tokyo Metropolitan Univ., 2.Oita Univ., 3.Chiba Inst. Technol., 4.Tohoku Univ.)

Keywords:cell membrane, plasma medicine, molecular dynamics

In plasma medicine, electrical effects, chemical effects, and light effects are intricately involved. However, the balance of influence and interaction of multiple factors remain unclear. In particular, the electrical effects of electric fields and currents are not fully understood. In this paper, the free energy profile and the membrane permeability coefficient of hydrogen peroxide (H₂O₂), one of the reactive oxygen species under electric field application, were derived from the simulation results of molecular interactions by molecular dynamics (MD).