The 56th Annual Meeting of the Japanese Society of Developmental Biologists

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Oral Presentation

Oral Presentation10 Transcriptional regulation & Epigenetics

Mon. Jul 24, 2023 12:45 PM - 2:15 PM Room A (2F Tachibana)

Chairpersons:Tatsuya Takemoto Takemoto(Tokushima Univ.), Nayuta Yakushiji-Kaminatsui(RIKEN IMS)

1:15 PM - 1:30 PM

[OP10e-3] Single-Cell CRISPR Activation Screen in Primary Embryonic Hepatocytes Identifies Potent Transcriptional Regulators for Metabolic Gene Activation and Embryonic Gene Suppression during Maturation

シングルセル解析をリードアウトとしたCRISPR Activationスクリーニングによる、胎児肝細胞の成熟分化における代謝関連分子の活性化および胎児型遺伝子の抑制を担う転写制御因子の同定

*Atsuhiro Taguchi1, Alexandre Magalhães1, Helene Kretzmer1, Denes Hnisz1, Lars Wittler1, Alexander Meissner1 (1. Max Planck Institute for Molecular Genetics)

Keywords:organoid, maturation, hepatocyte, CRISPR activation, single cell

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