[EngO6-4] Association between appropriate empiric antimicrobial therapy and mortality from bloodstream infections in the intensive care unit
Background: Empirical antimicrobial treatment for patients presenting with bloodstream infections is considered to affect patients' outcome.
Method: We conducted a single-center, retrospective study of critically-ill patients hospitalized in the intensive care unit, to examine whether the appropriate antimicrobial therapy was associated with mortality from bloodstream infections. Survival rate up to 60 days after the sampling of the blood cultures was analyzed.
Results: We enrolled a total of 62 patients with bloodstream infection, of whom 46 received appropriate and 16 received inappropriate, empirical, antimicrobial therapy. The 60-day mortality of the appropriately treated patients was significantly lower than that of the inappropriately treated patients (35% vs 88%; p=0.0003), with an adjusted odds ratio for death of 0.043 (95% confidence interval 0.0047 to 0.23; p=0.0011). Survival rate was significantly better in the appropriately treated patients compared with the inappropriately treated patients (p=0.0004), with an adjusted hazard ratio of 0.34 (95% confidence interval 0.16 to 0.70; p=0.0043).
Conclusion: Appropriate antimicrobial therapy might have been associated with lower 60-day mortality compared with inappropriate therapy in critically-ill patients with bloodstream infection.
Method: We conducted a single-center, retrospective study of critically-ill patients hospitalized in the intensive care unit, to examine whether the appropriate antimicrobial therapy was associated with mortality from bloodstream infections. Survival rate up to 60 days after the sampling of the blood cultures was analyzed.
Results: We enrolled a total of 62 patients with bloodstream infection, of whom 46 received appropriate and 16 received inappropriate, empirical, antimicrobial therapy. The 60-day mortality of the appropriately treated patients was significantly lower than that of the inappropriately treated patients (35% vs 88%; p=0.0003), with an adjusted odds ratio for death of 0.043 (95% confidence interval 0.0047 to 0.23; p=0.0011). Survival rate was significantly better in the appropriately treated patients compared with the inappropriately treated patients (p=0.0004), with an adjusted hazard ratio of 0.34 (95% confidence interval 0.16 to 0.70; p=0.0043).
Conclusion: Appropriate antimicrobial therapy might have been associated with lower 60-day mortality compared with inappropriate therapy in critically-ill patients with bloodstream infection.