[P22-03] 糖尿病母体児における心機能
Keywords:intraventricular pressure difference and gradients, cardiac diastolic function, gestational diabetes mellitu
[Background] Fetuses with gestational diabetes mellitus (GMD) present signs of ventricular diastolic dysfunction in deformation analysis during pregnancy. Recently, intraventricular pressure difference (IVPD) and gradients (IVPG) using color M-mode Doppler imaging of mitral valve inflow and the Euler equation are known as useful markers of myocardial diastolic function.[Methods and Results] The diagnosis of GDM is based on oral glucose tolerance test results during pregnancy. Pre-GDM is diabetes that starts before the current pregnancy. The median HbA1c level of the mothers was 5.8%. The study included 15 infants with GDM and 45 healthy infants as controls (GDM vs Controls: median birth weight [BW], 3166 vs 2948 g, P=0.06). Differences in intraventricular septum (IVS), IVPD, and IVPG between the groups were significant (GDM vs Control: IVS 3.7 vs 3.3 mm; IVPD, 1.15 vs 0.85 mmHg; IVPG, 0.38 vs 0.29 mmHg; P＜0.01]. IVS, IVPD, and IVPG positively correlated with the mother’s fasting blood glucose level. IVPD and IVPG negatively correlated with gestational weight gain and cord blood potassium.[Conclusio Sucking force after birth, measured as the IVPD and IVPG, was higher in the of infants with GDM than in the controls. Appropriate glucose balance for GDM might have favorable cardiac effects for infants after birth owing to increased cardiac muscle mass.