Eiji Hishinuma ¹, Fumika Akai ¹, Masamitsu Maekawa ², Noriyasu Hirasawa ¹, Masahiro Hiratsuka ^1,2,3 (1.Graduate School of Pharmaceutical Sciences, Tohoku University, 2.Department of Pharmacy, Tohoku University Hospital, 3.Tohoku Medical Megabank Organization)

Yasuhiro Kazuki ^1,2, Kaoru Kobayashi ³, Masumi Hirabayashi ⁴, Jiro Kuze ^1,5, Tetsushi Sakuma ⁶, Satoshi Abe ¹, Mari Hashimoto ³, Yasuko Tsukazaki ⁷, Naoto Senda ^1,7, Naoyo Kajitani ¹, Shoko Takehara ¹, Kanako Kazuki ¹, Takashi Yamamoto ^1,6, Kan Chiba ³, Mitsuo Oshimura ¹ (1.Chromosome Engineering Research Center, Tottori University, 2.Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, 3.Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 4.National Institute for Physiological Sciences, Center for Genetic Analysis of Behavior, 5.Taiho Pharmaceutical Co., Ltd., 6.Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 7.Tsukuba Bioanalytical Laboratory, Shin Nippon Biomedical Laboratories, Ltd.)

Satoshi Abe ¹, Kaoru Kobayashi ², Asami Oji ³, Tetsushi Sakuma ⁴, Kanako Kazuki ¹, Shoko Takehara ¹, Azusa Okada ², Yasuko Tsukazaki ⁵, Naoto Senda ^1,5, Takashi Yamamoto ⁴, Masahito Ikawa ³, Kan Chiba ², Mitsuo Oshimura ¹, Yasuhiro Kazuki ^1,6 (1.Chromosome Engineering Research Center, Tottori University, 2.Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 3.Animal Resource Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 4.Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 5.Tsukuba Bioanalytical Laboratory, Shin Nippon Biomedical Laboratories, Ltd., 6.Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University)

Satoru Iwado ¹, Daisuke Satoh ², Satoshi Abe ², Shinobu Wakuri ³, Yoshihiro Nakajima ⁴, Mitsuo Oshimura ², Yasuhiro Kazuki ^1,2 (1.Graduate School of Medical Sciences, Tottori University, 2.Chromosome Engineering Research Center, Tottori University, 3.Food and Drug Safety Center, 4.National Institute of Advanced Industrial Science and Technology)

Masataka Nakano, Tatsuki Fukami, Saki Gotoh, Miki Nakajima (Faculty of Pharmaceutical Sciences, Kanazawa University)

Yuki Shimizu, Michiko Watanabe, Saki Tsuchiya, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari (Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka)

Takeshi Susukida, Shigeki Aoki, Sota Fujimori, Kotaro Kogo, Kousei Ito (Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University)

Yayoi Yokozuka ¹, Eiko Matsumoto ¹, Kentaro Yano ¹, Takuo Ogihara ² (1.Laboratory of biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare, 2.Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare)

Yuri Ohba, Yusuke Masuo, Kohei Yamada, Noritaka Nakamichi, Munetaka Kunishima, Yukio Kato (Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan)

Mai Inagaki ¹, Tomohiro Nishimura ¹, Takeo Nakanishi ², Hiroaki Shimada ^2,3, Shin-ichi Akanuma ⁴, Masanori Tachikawa ⁵, Ken-ichi Hosoya ⁴, Ikumi Tamai ², Emi Nakashima ¹, Masatoshi Tomi ¹ (1.Faculty of Pharmacy, Keio University, 2.Faculty of Pharmaceutical Sciences, Kanazawa University, 3.Faculty of Pharmacy, Kindai University, 4.Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 5.Graduate School of Pharmaceutical Sciences, Tohoku University)

Takeshi Miyake, Tadahaya Mizuno, Tatsuki Mochizuki, Hiroyuki Kusuhara (Lab. of Molecular Pharmacokinetics, the University of Tokyo)

Ryosuke Negoro ¹, Kazuo Takayama ^1,2,3, Masashi Tachibaba ¹, Huminori Sakurai ¹, Hiroyuki Mizuguchi ^1,3,4 (1.Graduate School of Pharmaceutical Sciences, Osaka University, 2.The Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research, 3.National Institutes of Biomedical Innovation, Health and Nutrition, 4.Global Center for Medical Engineering and Informatics, Osaka University)