Oral Presentation

[O5] 5．Pharmacokinetics

Fri. Oct 14, 2016 3:38 PM - 5:02 PM Room 5 (The first meeting room)

Masahiro Iwaki (Faculty of Pharmacy, Department of Pharmacy, Kindai University), Koji Chiba (Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy), Satomi Onoue (Department of Pharmacokinetics and Pharmacodynamicsm School of Pharmaceutical Sciences, University of Shizuoka), Hiroaki Yuasa (Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University), )

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[O5-1] Novel solid dispersions of carvedilol with microenvironmental pH-modifiers to improve pharmacokinetic properties under hypochlorhydria

Shimul Halder ^1,2, Hideyuki Sato ¹, Yoshiki Seto ¹, Satomi Onoue ¹ (1.Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 2.Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka)

[O5-2] Pharmacokinetic transition of itraconazole induced by feeding and its avoidance upon self-micellizing solid dispersion system

Hideyuki Sato, Kanako Kobayashi, Saori Matsunaga, Yoshiki Kojo, Hiroki Suzuki, Yoshiki Seto, Satomi Onoue (Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka)

[O5-3] Physiologically-based pharmacokinetic modeling and simulation of tacrolimus in living-donor liver transplantation: Effects of liver regeneration and CYP3A5 genotype

Kotaro Itohara ¹, Ikuko Yano ^1,2, Tetsunori Tsuzuki ¹, Shunsaku Nakagawa ¹, Atsushi Yonezawa ¹, Hideaki Okajima ³, Toshimi Kaido ³, Shinji Uemoto ³, Kazuo Matsubara ¹ (1.Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, 2.Department of Pharmacy, Kobe University Hospital, 3.Department of Surgery, Graduate School of Medicine, Kyoto University)

[O5-4] “Albumin-mediated” hepatic transport: extrapolation to in vivo hepatic clearance from in vitro uptake data by suspended human hepatocytes in the presence of varied albumin concentrations

Yuichi Sugiyama ¹, Soo-Jin Kim ¹, Kyeong Ryoon Lee ¹, Seiji Miyauchi ² (1.Sugiyama Lab., RIKEN Innovation Center, RIKEN, Yokohama, 2.Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba)

[O5-5] Analysis of complex drug-drug interactions of cerivastatin using physiologically based pharmacokinetic (PBPK) modeling

Yoshiaki Yao ¹, Kota Toshimoto ², Soo-Jin Kim ², Takashi Yoshikado ², Yuichi Sugiyama ² (1.Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan, 2.Sugiyama Lab, RIKEN Innovation Center, RIKEN, Yokohama, Japan)

[O5-6] Estimation of hepatic uptake transporter OATP1B1 variability: Influence of passive diffusion and metabolic intrinsic clearance on repaglinide AUC variability

Koji Chiba ^1,2, Hiroki Takahashi ¹, Soo-Jin Kim ², Tomohiko Takatsu ¹, Yuichi Sugiyama ² (1.Yokohama University of Pharmacy, 2.Sugiyama Laboratory, RIKEN Innovation Center)

[O5-7] The novel physiologically based pharmacokinetics (PBPK) model to investigate transporter-mediated disposition and clearance of metformin in humans

Kotaro Nishiyama ¹, Kota Toshimoto ², Naoki Ishiguro ¹, Yuichi Sugiyama ² (1.Nippon Boehringer Ingelheim Co., Ltd., 2.Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Yokohama)