31th JSSX Annual Meeting in Matsumoto The Japanese Society for the Study of Xenobiotics

Session information

Print

Oral Presentation

[O6] 6．Drug interaction・Toxicity

Sat. Oct 15, 2016 9:00 AM - 10:12 AM Room 5 (The first meeting room)

Kiyomi Ito (Research Institute of Pharmaceutical Sciences, Musashino University), Akihiro Hisaka (Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University), Yasuhiro Masubuchi (Chiba Institute of Science), Ryoichi Fujiwara (School of Pharmacy, Kitasato University), )

[O6-1] Clopidogrel-mediated drug-drug interaction on CYP2C8 and OATP1B1: in vitro inhibitory effect and in vivo clinical study

Soo-Jin Kim 1, Takashi Yoshikado 1, Ichiro Ieiri 2, Kazuya Maeda 3, Miyuki Kimura 4, Shin Irie 4, Hiroyuki Kusuhara 3, Yuichi Sugiyama 1 (1.Sugiyama Lab., RIKEN Innovation Center, RIKEN, Yokohama, 2.Department of Clinical Pharmacokinetic, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 3.Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 4.Sugioka Memorial Hospital, Fukuoka)

[O6-2] PBPK model of rifampicin incorporating its hepatic uptake and auto-induction processes to predict various types of DDIs such as CYP3A/2C9 inductions and OATPs inhibitions

Ryuta Asaumi 1, Kota Toshimoto 2, Toshiyuki Kudo 3, Takeshi Sawada 1, Yoshifusa Tobe 1, Kenta Kono 1, Kiyomi Ito 3, Kenichi Nunoya 1, Haruo Imawaka 1, Yuichi Sugiyama 2 (1.Pharmacokinetic Reserch Laboratories, Ono Pharmaceutical Co.,Ltd., 2.Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, 3.Research Institute of Pharmaceutical Sciences, Musashino University)

[O6-4] Analysis of mechanism-based inhibition of cytochrome P450 3A4 by a series of in-house fluoroquinolone antibacterial agents

Akiko Watanabe 1, Hideo Takakusa 1, Takako Kimura 2, Shin-ichi Inoue 1, Hiroyuki Kusuhara 3, Osamu Ando 1 (1.Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., 2.Structural Biology Group, Biological Research Department, Daiichi Sankyo RD Novare Co., Ltd., 3.Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Science, The University of Tokyo)

[O6-5] Species and substrate dependent differences in inhibitory effects of drugs on aldehyde oxidase between mice and humans

Naoki Takaoka 1, Seigo Sanoh 1, Katsuhiro Okuda 2, Yuji Ishida 3, Ami Yanagi 3, chise Tateno 3, Yoshitaka Tayama 4, Kazumi Sugihara 4, Kitamura Shigeyuki 5, Mineko Terao 6, Enrico Garattini 6, Shigeru Ohta 1 (1.Graduate School of Biomedical and Health Sciences, Hiroshima University, 2.Asahikawa Medical University, 3.PhenixBio Co. Ltd, 4.Faculty of Pharmaceutical Sciences, Hiroshima International University, 5.Nihon Pharmaceutical University, 6.Laboratory of Molecular Biology, Institute di Ricerche Farmacologie “Mario Negri”, Italy)