Yuma Ishizaki ¹, Tomomi Furihata ^1,2, Kayoko Ohura ³, Teruko Imai ³, Masakiyo Hosokawa ⁴, Hidetaka Akita ¹, Kan Chiba ¹ (1.Graduate School of Pharmaceutical Science, Chiba University, 2.Graduate School of Medicine, Chiba University, 3.Graduate School of Pharmaceutical Science, Kumamoto University, 4.Faculty of Pharmacy, Chiba Institute of Science)

Koichi Takahashi ^1,2, Kunihiro Yoshisue ¹, Masato Chiba ¹, Takeo Nakanishi ², Ikumi Tamai ² (1.Pharmacokinetics Research Laboratories, Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., 2.Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University)

Hisanao Kishimoto, Nanami Murata, Miho Muratani, Kaori Miyazaki, Yoshiyuki Shirasaka, Katsuhisa Inoue (Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)

Rika Oda, Yoshiyuki Shirasaka, Akari Eguchi, Kazuki Ichijo, Ren Okada, Marika Ishihara, Yuri Moteki, Yuta Funai, Takuya Horiuchi, Hisanao Kishimoto, Katsuhisa Inoue (School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)

Ryo Kinoshita ¹, Yu Ishima ², Mayumi Ikeda ¹, Hideaki Nakamura ^3,4, Jun Fang ^3,4, Hiroshi Maeda ^3,4, Hiroshi Watanabe ^1,5, Masaki Otagiri ^3,4, Toru Maruyama ^1,5 (1.Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 2.Department of Pharmacokinetics and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Tokushima University, Japan, 3.Faculty of Pharmaceutical Sciences, Sojo University, Japan, 4.DDS Research Institute, Sojo University, Japan, 5.Center for Clinical Pharmaceutical Sciences, School of Pharmacy, Kumamoto University, Japan)

Takafumi Ueyama ¹, Keiko Sawabe ², Masae Morita ², Yasuhiko Ohkaru ², Anita Kurunczi ³, Zsolt Fekete ³, Emese Kis ³, Makoto Kitaura ¹ (1.KAC Co., Ltd., Cell Technology, Japan, 2.KAC Co., Ltd., Reagents Business, Japan, 3.SOLVO Biotechnology, Hungary)

Hanae Morio ¹, Tomomi Furihata ^1,2, Meiyan Zhu ¹, Akira Koibuchi ¹, Hideyuki Ide ¹, Minaka Shibuya ¹, Atsuko Kamiichi ¹, Kan Chiba ¹, Naohiko Anzai ², Hidetaka Akita ¹ (1.Graduate School of Pharmaceutical Sciences, Chiba University, 2.Graduate School of Medicine, Chiba University)

Genki Nakamura, Motohiro Kato, Koji Yamaguchi, Miho Nagayasu, Takeru Nambu, Takayuki Nemoto, Kazuhisa Ozeki, Masaki Ishigai (Chugai pharmaceutical Co., Ltd.)

Makoto Kodama ¹, Yuki Kinoshita ¹, Takehiko Aoki ², Yoshinori Kanahama ² (1.Vessel Inc., 2.Cosmo Bio Co.Ltd.)

Motohiro Kato, Haruka Tsutsui, Masaki Ishigai (Chugai Pharmaceutical Co.Ltd.)

Kanako Yajima ^1,2, Norie Murayama ², Yasuhiro Uno ¹, Masahiro Utoh ^1,2, Kazuhide Iwasaki ¹, Hiroshi Yamazaki ² (1.Shin Nippon Biomedical Laboratories, Ltd., 2.Showa Pharmaceutical University)

Takayuki Taguchi, Yusuke Masuo, Noritaka Nakamichi, Yukio Kato (Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan)

Saki Omote, Hiroshi Arakawa, Takeo Nakanishi, Ikumi Tamai (Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan)

Kaori Yasuda, Sera Ueno, Kasumi Itoh, Kairi Okamoto, Miyu Nishikawa, Masaki Kamakura, Shinichi Ikushiro, Toshiyuki Sakaki (Department of Biotechnology, Toyama Prefectural University)

Mika Nagai ^1,2, Yoshihiro Konno ¹, Kouichi Yoshinari ³ (1.Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical Co., Ltd., 2.Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 3.Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka)

Takuomi Hosaka ¹, Mika Nagai ^1,2, Takamitsu Sasaki ¹, Yoshihiro Konno ², Kouichi Yoshinari ¹ (1.Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 2.Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical Co., Ltd.)

Yuichi Ichimura ¹, Natsumi Kudoh ¹, Takayuki Komukai ¹, Takanao Suzuki ¹, Hideyuki Suga ^1,2, Masako Oda ¹, Hiroshi Saitoh ¹ (1.Department of Pharmaceutics, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 2.Department of Pharmacy, Hokusei Hospital)

Takahiro Kubota ¹, Shun-ichi Odahara ², Kan Uchiyama ², Zensho Ito ², Shin-ichiro Takami ², Hiroko Kobayashi ², Keisuke Saito ², Shigeo Koido ², Toshifumi Ohkusa ² (1.Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 2.The Jikei University School of Medicine (Kashiwa Hospital))

Takeshi Hirota, Keisuke Gotanda, Tomoko Tokumoto, Masato Fukae, Ichiro Ieiri (Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Science, Kyushu University)

Hidetoshi Hashizume ¹, Motoki Onishi ¹, Maki Matsuda ¹, Yuka Haruna ¹, Maiko Jikou ¹, Kozo Tagawa ¹, Jo Tanaka ², Sayuri Migita ² (1.Towa Pharmaceutical Co., Ltd., 2.Shin Nippon Biomedical Laboratories, Ltd.)

Yukiko Yazaki, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda (Kyoto Pharmaceutical University)

Mika Ishikawa, Shota Kamada, Minami Ito, Shunsuke Sasaki, Teruki Yoshimura, Daisuke Kobayashi, Keiji Wada (School of Pharmaceutical Sciences, Health Sciences University of Hokkaido)

Ryuichi Harada, Yoshiyuki Yamaura, Haruo Imawaka (ONO PHARMACEUTICAL CO.,LTD.)

Nobuyuki Takahashi ¹, Tomonori Sugimoto ¹, Yumiko Iwase ¹, Nagahiko Yumita ¹, Koji Chiba ^1,2, Norie Murayama ³, Hiroshi Yamazaki ^2,3, Toshihiko Ikeda ² (1.Yokohama University of Pharmacy, 2.Association for Promoting Drug Development, 3.Showa Pharmaceutical University)

Takashi Shimada ¹, Noriko Iwamoto ¹, Megumi Takanashi ¹, Akinobu Hamada ² (1.SHIMADZU Corporation, 2.National Cancer Center Research Institute)

Shiori Taniguchi, Chika Sakai, Fumiyoshi Yamashita, Mitsuru Hashida (Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University)

Noriyuki Ishihara ^1,2, Nobuhiho Nishimura ¹, Kazuro Ikawa ², Hiroki Tamaki ¹, Fumi Karino ³, Kiyotaka Miura ³, Takeshi Isobe ³, Norifumi Morikawa ², Kohji Naora ¹ (1.Department of Pharmacy, Shimane University Hospital, 2.Department of Clinical Pharmacotherapy, Hiroshima University, 3.Department of Internal Medicine, Division of Medical Oncology and Respiratory Medicine, Shimane University Faculty of Medicine)

Thanai Paxton ¹, Nikunj Tanna ², Kerri Smith ², Mark Wrona ², Leonard Dillon ³, Mark Roberts ³ (1.Nihon Waters K.K., 2.Waters Corporation US, 3.Waters Corporation UK)

Hirotaka Miyamoto ¹, Ayako Tokunaga ¹, Nanzi Shi ², Hisashi Hamasaki ^1,3, Shintaro Fumoto ¹, Koyo Nishida ¹ (1.Graduate School of Biomedical Sciences, Nagasaki University, 2.Faculty of Science, China Pharmaceutical University, 3.Department of Hospital Pharmacy, Nagasaki University Hospital)

László Szilágyi, Viktória Juhász, Bea Tóth, Roelof. H. de Wilde, Takeshi Sakata, Zsolt Fekete (SOLVO Biotechnology, Budaörs, Hungary)

Ryosuke Nakano ¹, Tomohide Uno ¹, Yuichiro Obe ¹, Chika Ogura ¹, Kengo Kanamaru ¹, Hiroshi Yamagata ¹, Hiromasa Imaishi ² (1.Laboratory of Biochemistry, Graduate School of Agricultural Science, Kobe University, 2.Research Center for Environmental Genomics, Kobe University)

Takayuki Amano, Tatsuki Fukami, Keigo Konishi, Saki Gotoh, Miki Nakajima (Faculty of Pharmaceutical Sciences, Kanazawa University)

Kazuhisa Honma ¹, Satoshi Abe ², Teruhiko Suzuki ³, Mitsuo Oshimura ², Yasuhiro Kazuki ^1,2 (1.Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 2.Chromosome Engineering Research Center, Tottori University, 3.Stem Cell Project, Tokyo Metropolitan Institute of Medical Science)

Satoshi Kitaoka, Wataru Ochiai, ryuuki Iimura, Jo Hatogai, Misa Iizuka, Konomi Oba, Osamu Kosaka, Mami Nakai, Tomoka Yasukawa, Hiroyuki Yoshida, Nobutomo Ikarashi, Kiyoshi Sugiyama (Department of Clinical Pharmacokinetics Hoshi University)

Toshiro Niwa ¹, Takako Hirai ¹, Shiho Eto ¹, Norie Murayama ², Hiroshi Yamazaki ² (1.School of Pharmacy, Shujitsu University, 2.Showa Pharmaceutical University)

Sho Nishinoaki, Ryo Fujino, Kenta Hashizume, Shinsuke Aoyama, Shin-ichi Ninomiya (Drug Development Solutions Center, Drug Development Solutions Division, Sekisui Medical Co., Ltd.)

Kanokwan Jarukamjorn ¹, Nadta Sukkasem ¹, Waranya Chatuphonprasert ^1,2 (1.PANPB Research Group, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002 Thailand, 2.Faculty of Medicine, Mahasarakham University, Mahasarakham 44000 Thailand)

Tomokazu Ohnuma, Hikaru Arai, Chiaki Takagi, Saki Watanabe, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka (Tokyo University of Pharmacy and Life Sciences)

Yuki Asai, Miki Katoh, Yukiko Sakakibara, Masayuki Nadai (Faculty of Pharmacy, Meijo University)

Daisuke Aibara ¹, Kimihiko Matsusue ¹, Kohei Matsuo ¹, Soichi Takiguchi ², Shigeru Yamano ¹ (1.Faculty of Pharmaceutical Science, Fukuoka University, 2.Insutitute for Clinical Research, National Kyushu Cancer Center)

Masato Ohbuchi ¹, Kazuhiro Tetsuka ¹, Hiroyuki Moriguchi ¹, Eisuke Kobayashi ², Yasuhisa Nagasaka ¹, Kenji Tabata ¹ (1.Analysis & Pharmacokinetics Research Laboratories, Astellas Pharma Inc., 2.Drug Safety Research Laboratories, Astellas Pharma Inc.)

Yoshimasa Saito ^1,2, Tadashi Kumamoto ³, Ikumi Tamai ², Chitose Ogawa ³, Hiroyuki Terakado ¹ (1.Department of Pharmacy, National Cancer Center Hospital, Tokyo, Japan, 2.Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 3.Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan)

Mina Yoshida, Kaoru Kobayashi, Naoki Cho, Hidetaka Akita, Kan Chiba (Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan)

Junya Deguchi, Masashi Kawami, Ryoko Yumoto, Mikihisa Takano (Graduate School of Biomedical & Health Sciences, Hiroshima University)

Etsuko Suzuki ¹, Futoshi Sato ¹, Tatsuya Ezaki ¹, Yasuko Matsui ², Ryosuke Kon ² (1.Nihon Waters K.K., 2.Wako Pure Chemical Industries, Ltd.)

Ryo Fujino, Toshimasa Ito, Kenta Hasidume, Shinsuke Aoyama, Shinichi Ninomiya (Drug Development Solutions Division, Sekisui Medical Co., Ltd.)

Masayoshi Mizuochi ¹, Tomonori Iwanami ², Hiroyuki Komatsu ², Aki Koyama ¹, Yasuki Akie ², Kaneo Sekiguchi ¹ (1.Bioanalysis Business Department, CMIC Pharma Science Co., Ltd., 2.Bioresearch Center, CMIC Pharma Science Co., Ltd.)

Masahiro Segawa ^1,2, Shuichi Sekine ¹, Tomoyuki Sato ¹, Koichi Arakawa ¹, Yugo Ikeyama ¹, Kosuke Saito ³, Yoshiro Saito ³, Kousei Ito ¹ (1.Laboratoy of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 2.Drug Metabolism & Pharmacokinetics, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 3.Division of Medicinal Safety Science, National Institute of Health Sciences)

Mayuko Tokizono ¹, Shuichi Sekine ¹, Eiichiro Ogimura ², Takeshi Susukida ¹, Kousei Ito ¹ (1.Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 2.Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd.)

Tomohiro Nabekura, Tomoji Kaneko, Michi Furuta, Tatsuya Kawasaki, Yuichi Uwai (School of Pharmacy, Aichi Gakuin University)

Mioka Miyamoto ¹, Natsuko Honda ², Ryoko Yumoto ¹, Masashi Kawami ¹, Mikihisa Takano ¹ (1.Graduate School of Biomedical & Health Sciences, Hiroshima University, 2.Faculty of Pharmaceutical Sciences, Hiroshima University)

Ken-ichi Hosoya, Ayumi Nakazawa, Shin-ichi Akanuma, Yoshiyuki Kubo (University of Toyama)

Tatsuya Kawasaki, Yoshiyasu Takeichi, Masashi Tomita, Yuichi Uwai, Tomohiro Nabekura (School of Pharmacy, Aichi Gakuin University)

Ayako Furugen ¹, Yuri Ishiguro ¹, Masaki Kobayashi ², Katsuya Narumi ¹, Ayako Nishimura ², Ken Iseki ^1,2 (1.Faculty of Pharmaceutical Sciences, Hokkaido University, 2.Department of Pharmacy, Hokkaido University Hospital)

Rina Ohnishi ¹, Kanako Kazuki ², Daisuke Satoh ², Akane Morita ³, Satoshi Abe ², Mitsuo Oshimura ², Yasuhiro Kazuki ^1,2 (1.Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, 2.Chromosome Engineering Research Center, Tottori University, 3.Division of Molecular and Cell Genetics, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University)

Saki Toyota, Hiroki Ito, Ryoko Yumoto, Mikihisa Takano (Graduate School of Biomedical & Health Sciences, Hiroshima University)

Rika Aotani, Takeo Nakanishi, Shunsuke Kamo, Tomoka Gose, Ikumi Tamai (Faculty of Pharmaceutical Sciences, Kanazawa University)

Rina Ainaka, Yusuke Masuo, Tomoyuki Yoshimura, Noritaka Nakamichi, Jun-ichi Matsuo, Yukio Kato (Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University)

Toshiki Kurosawa ¹, Kei Higuchi ¹, Takashi Okura ¹, Hiroyuki Kusuhara ², Yoshiharu Deguchi ¹ (1.Faculty of Pharma-Sciences, Teikyo University, 2.Graduate School of Pharmaceutical Sciences, The University of Tokyo)

Tomoka Gose, Takeo Nakanishi, Ikumi Tamai (Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University)

Akane Hosoma ¹, Tomoya Yasujima ¹, Kinya Ohta ², Hiroaki Yuasa ¹ (1.Graduate School of Pharmaceutical Sciences, Nagoya City University, 2.School of Pharmacy, Kinjo Gakuin University)

Carina Cantrill, Nicole Stone, Michael Hall (Quotient Bioresearch (Rushden) Ltd., Crown Business Park, Pegasus Way, Rushden, Northamptonshire, NN10 6ER, United Kingdom)

Ju-Young Park ¹, Hiroyuki Moriguchi ², Hiroe Yamamoto ¹, Akihiko Takeuchi ¹, Tomoko Kojima ¹, Kenji Tabata ², Koichi Shiozuka ¹ (1.Drug Metabolism & Pharmacokinetics Research Div., Astellas Research Technologies Co. Ltd, 2.Analysis & Pharmacokinetics Research Labs, Astellas Pharma Inc.)

Shin-ichi Akanuma, Hirokazu Shimada, Yoshiyuki Kubo, Ken-ichi Hosoya (Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama)

Yuki Matsumoto, Takafumi Iwatsubo, Satoki Imai, Kaoru Kobayashi, Hiroshi Kodaira, Shingo Sakamoto, Masakazu Shibata, Yoshikazu Kurahashi, Shin-ichi Miura (Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association)

Kazuko Nishimura ¹, Shinko Hata ², Tsutomu Hashimoto ³, Tamiki Mori ³, Takahiro Nakamura ⁴, Tatsuki Nomura ⁴, Tetsu Saito ⁵, Kyoko Minoura ⁵, Muneo Aoyama ⁶, Jun Hosogi ⁷, Masako Soma ⁸, Kenta Kadotsuji ⁹, Kazuhiro Nishimiya ¹⁰, Noriko Katori ¹, Norihisa Sakamoto ¹¹, Akiko Ishii-Watabe ¹ (1.National Institute of Health Sciences, 2.Ig-M Corporation, 3.LSI Medience Corporation, 4.Shin Nippon Biomedical Laboratories, Ltd., 5.Astellas Pharma Inc., 6.Eisai Co., Ltd., 7.Kyowa Hakko Kirin Co., Ltd., 8.Daiichi Sankyo Co., Ltd., 9.Sumitomo Dainippon Pharma Co., Ltd., 10.Chugai Pharmaceutical Co., Ltd., 11.Pharmaceuticals and Medical Devices Agency)

Seiji Mitani ¹, Kazuo Takayama ², Masashi Tachibana ², Fuminori Sakurai ², Hiroyuki Mizuguchi ² (1.Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, JapanBiochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, 2.Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan)

Ryosaku Ohta ¹, Fumiyoshi Yamashita ¹, Nagomi Kurebayashi ², Takashi Murayama ², Mitsuru Hashida ^1,3 (1.Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 2.Department of Pharmacology, School of Medicine, Juntendo University, 3.Institute for Integrated Cell-Material Sciences, Kyoto University)

Takafumi Nakano ¹, Kazuma Hamada ¹, Kyoji Moriya ², Kazuhiko Koike ², Toshiharu Horie ¹ (1.Biopharmaceutical and Molecular Toxicology Unit, Faculty of Pharmaceutical Sciences, Teikyo Heisei University, 2.Department of Internal Medicine, Graduate School of Medicine, The University of Tokyo)