Symposium

[SY-16] Symposium16
Humanized animal models for drug metabolism studies: current state and issues

Sat. Oct 15, 2016 1:20 PM - 3:50 PM Room 1 (Great hall)

Miki Nakajima (Faculty of Pharmaceutical Sciences, Kanazawa University), Kaoru Kobayashi (Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University), Yoichi Naritomi (Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.)

+Add all to schedule

[SY-16-01] CYP3A-humanized mouse model generated by chromosome engineering technology to predict pharmacokinetics and toxicity in humans

Kaoru Kobayashi ¹, Yasuhiro Kazuki ^2,3 (1.Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 2.Graduate School of Medical Sciences, 3.Chromosome Engineering Research Center, Tottori University)

[SY-16-02] Recent research in humanized UDP-glucuronosyltransferase 1 mice: Prediction of glucuronidation of drugs and endogenous substances in humans

Ryoichi Fujiwara (Department of Pharmaceutics, School of Pharmacy, Kitasato University)

[SY-16-03] Prediction of human metabolism using chimeric mice with humanized liver and Cyp3a knockout humanized liver mice

Naoyuki Nakada (Analysis&Pharmacokinetics Research Laboratories, Astellas Pharma Inc.)

[SY-16-04] Combining mice with humanized liver, mass spectrometry, and physiologically-based pharmacokinetic modeling

Hiroshi Yamazaki (Showa Pharmaceutical University)

[SY-16-05] Generation of functional human organ from pluripotent stem cell

Hideki Taniguchi, Takanori Takebe (Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, JAPAN)