Estimation of hepatic uptake transporter OATP1B1 variability: Influence of passive diffusion and metabolic intrinsic clearance on repaglinide AUC variability

Koji Chiba

Presentation information

Oral Presentation

[O5] 5．Pharmacokinetics

Fri. Oct 14, 2016 3:38 PM - 5:02 PM Room 5 (The first meeting room)

Masahiro Iwaki (Faculty of Pharmacy, Department of Pharmacy, Kindai University), Koji Chiba (Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy), Satomi Onoue (Department of Pharmacokinetics and Pharmacodynamicsm School of Pharmaceutical Sciences, University of Shizuoka), Hiroaki Yuasa (Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University), )

[O5-6] Estimation of hepatic uptake transporter OATP1B1 variability: Influence of passive diffusion and metabolic intrinsic clearance on repaglinide AUC variability

Koji Chiba ^1,2, Hiroki Takahashi ¹, Soo-Jin Kim ², Tomohiko Takatsu ¹, Yuichi Sugiyama ² (1.Yokohama University of Pharmacy, 2.Sugiyama Laboratory, RIKEN Innovation Center)

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