31th JSSX Annual Meeting in Matsumoto The Japanese Society for the Study of Xenobiotics

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Oral Presentation

[O6] 6．Drug interaction・Toxicity

Sat. Oct 15, 2016 9:00 AM - 10:12 AM Room 5 (The first meeting room)

Kiyomi Ito (Research Institute of Pharmaceutical Sciences, Musashino University), Akihiro Hisaka (Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University), Yasuhiro Masubuchi (Chiba Institute of Science), Ryoichi Fujiwara (School of Pharmacy, Kitasato University), )

[O6-2] PBPK model of rifampicin incorporating its hepatic uptake and auto-induction processes to predict various types of DDIs such as CYP3A/2C9 inductions and OATPs inhibitions

Ryuta Asaumi 1, Kota Toshimoto 2, Toshiyuki Kudo 3, Takeshi Sawada 1, Yoshifusa Tobe 1, Kenta Kono 1, Kiyomi Ito 3, Kenichi Nunoya 1, Haruo Imawaka 1, Yuichi Sugiyama 2 (1.Pharmacokinetic Reserch Laboratories, Ono Pharmaceutical Co.,Ltd., 2.Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, 3.Research Institute of Pharmaceutical Sciences, Musashino University)

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