[HT-05-3] Muscle diseases with autophagic abnormalities
Autophagy sequesters cytoplasmic material and organelles to lysosomes for degradation. The magnitude of autophagy depends on starvation, oxidative stress, or other noxious conditions, which thereby exerts quality control function that contributes to neurodegeneration and aging. The lysosome was once thought of as a waste bag, a dead-end destination where cellular debris was sent for disposal. However, recent studies have challenged this simple view and found that Lysosomes are not just a sack of digestive enzymes, but rather a signaling/sorting hub related to all of the materials used in the cell. In this symposium, we will invite four speakers with known expertise to share the recently discovered properties of the autophagy-lysosome system in neurological conditions and offer helpful hints on how to develop therapeutic strategies to combat these devastating diseases.
Dr. Ichizo Nishino, is Director of Department of Neuromuscular Research, National Institute of Neuroscience (NIN), NCNP. He is also serving as a Visiting Professor in 4 universities, including those in Taiwan and Thailand.
Dr. Nishino obtained his M.D. in 1989 from Kyoto University. After 5 years of neurology training, he started muscle disease research. He was appointed to Section Chief in NIN, NCNP in 2000, and to the current position in 2001. By now, he has published >480 PubMed-listed papers in the field.
His laboratory functions as a referral center for muscle disease, providing diagnostic service for muscle pathology and genetic analysis, collecting more >70% of muscle biopsies performed in Japan (1093 cases in 2018). Not surprisingly, his muscle repository is one of the largest collections in the world
Dr. Nishino is a corresponding Fellow of AAN and ANA; Vice President of Asian and Oeceanian Myology Center; and an Executive Board Member for a number of academic societies.
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