[S-28] New concepts of glia and brain homeostasis: key missing pieces in the puzzle of neurological disorders

[S-28-3] Reactive Astrocytes, MAO-B, GABA, Hydrogen Peroxide, and Alzheimer's Disease

C. Justin Lee (Institute for Basic Science)

During the last few years, novel concepts of glia and glymphatic system have dramatically yielded unexpected results that challenge the traditional view of neurological disorders including Alzheimer's disease and other neurodegenerative diseases. They also play a crucial role in maintaining brain homeostasis. This symposium will highlight the latest developments in the reserch of glia and glymphatic system for the CNS in health and disease.

Education
Undergraduate:
The University of Chicago, Chicago, IL, USA
B.A. in Chemistry, June 1990

Graduate:
Columbia University, New York, Graduate School of Arts and Sciences
Department of Physiology and Cellular Biophysics
PhD, May 16th, 2001
Thesis advisor: Dr. Amy B. MacDermott
Dissertation Title: The Expression and Function of Kainate and AMPA Receptors in Nociceptive Dorsal Root Ganglion Neurons.

Post Doctoral:
Emory University, Atlanta, GA, USA, Department of Pharmacology
Post Doctoral Fellow, Mar 2001 ~ Aug 2004
(Sponsor: Dr. Stephen Traynelis)
Project Scope: Modulation of NMDA receptors by protease activated receptors (PAR).

Selected Recent Publications:
1. Proc Natl Acad Sci U S A. 2018 Apr 24.
2. Molecular Psychiatry. 2018 Apr;23(4):1021-1030.
3.Nat Med. 2014 Aug;20(8):886-96
4. J Physiol. 2014 Nov 15;592(22):4951-68.
5. Nat Commun. 2014 Feb 5;5:3227
6. Cell 2012 Sep 28;151(1):25-40
7. Science. 2010 Nov 5;330(6005):790-6
8. Cancer Research, 2010 Feb 1;70(3):1173-83
9. J of Neuroscience, 2009 Oct 14;29(41):13063-73