[S-35] Progressive multifocal leukoencephalopathy in the era of disease-modifying therapies

[S-35-5] Genetic backgrounds of Japanese MS and JC virus antibody

Noriko Isobe (Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan)

Progressive multifocal leukoencephalopathy (PML) is a rare and severe demyelinating disease of the white matter in the central nervous system caused by JC virus. Multiple sclerosis (MS) treating with disease-modifying therapies (DMT) is newly coming underlying disease of PML. In MS, DMT have recently been shown to reduce the frequency and severity of clinical relapse. Although freedom from disease activity has become the primary aim of the treatment of MS, these DMT increase the risk of PML.
In this symposium, latest information of DMT induced PML, characteristics of MRI in DMT induced PML, development of JC virus DNA detection in the cerebrospinal fluid, and newly aspects of PML will be presented.

Education, Training and Professional Experience:
1997-2003 M.D., School of Medicine, Kyushu University
2003-2004 Resident, Kyushu University Hospital
2004-2007 Neurological Resident, Department of Neurology, Kyushu University Hospital and Saiseikai Fukuoka General Hospital
2007-2010 Ph.D., Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
2010-2017 Postdoctoral fellow/Specialist, Department of Neurology, University of California, San Francisco, the United States
2017-present Associate Professor, Department of Neurological Therapeutics, Kyushu University

Awards and Honors:
2011 Post-doctoral Fellowship, The Uehara Memorial Foundation
2012-2014 Postdoctoral Fellowship for Research Abroad, Japan Society for the Promotion of Science (JSPS)
2014-2015 Research Fellowship for Young Scientists (PD), JSPS