[2P] D. Homeostatic and Neuroendocrine Systems

[2P-378] Chronic sleep fragmentation accelerates the onset of prodromal symptoms in Parkinson's disease model mice

*Masayuki Miyazaki^1,2,3, Hiroko Yagihara¹, Hiromi Fujita⁴, Hodaka Yamakado⁵, Keiji Wada⁴, Eiko N Minakawa^1,5 (1. Dept Neurophys, Natl Inst Neurosci, Natl Ctr of Neurol and Psychiatr, Tokyo, Japan, 2. Grad Sch Med Dent Sci, Tokyo Med and Dent Univ, Tokyo, Japan, 3. Research Fellow of Japan Society for the Promotion of Science, Japan Society for the Promotion of Science, 4. Dept Degen Neurol Dis, Natl Inst Neurosci, Natl Ctr of Neurol and Psychiatr, Tokyo, Japan, 5. Dept Neurol, Grad Sch Med, Kyoto Univ, Kyoto, Japan)

Keywords:Sleep fragmentation, Parkinson's disease, Prodromal symptoms