[3O05m2] Synaptic Plasticity / Posttranslational Modulation and Proteolysis

[3O05m2-03] Identification of a novel protein-uptake pathway in lysosomes required for neuromuscular homeostasis

*Yuuki Fujiwara^1,2, Viorica Raluca Contu¹, Chihana Kabuta¹, Megumu Ogawa¹, Mitsuki Miyagi³, Ryohei Sakai¹, Katsunori Hase¹, Mari Suzuki⁴, Ikuko Koyama-Honda⁵, Michio Inoue¹, Yasushi Ohya⁶, Yukiko Inoue¹, Ryuji Kawano³, Takayoshi Inoue¹, Ryosuke Takahashi⁷, Ichizo Nishino¹, Keiji Wada¹, Satoru Noguchi¹, Tomohiro Kabuta¹ (1. National Institute of Neuroscience, National Center of Neurology and Psychiatry, 2. United Graduate School of Child Development, Osaka University, 3. Faculty of Engineering, Tokyo University of Agriculture and Technology, 4. Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, 5. Graduate School of Medicine, The University of Tokyo, 6. Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, 7. Graduate School of Medicine, Kyoto University)

Keywords:lysosome/autophagy, proteolysis/protein degradation, neuropathy/myopathy, direct-uptake-via/through-membrane-protein (DUMP)