[4O05a1] Alzheimer's Disease and Dementia 2

[4O05a1-03] HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology

*Hikari Tanaka¹, Kanoh Kondo¹, Kyota Fujita¹, Hidenori Homma¹, Kazuhiko Tagawa¹, Xiaocen Jin¹, Meihua Jin¹, Yuki Yoshioka¹, Sumire Takayama¹, Hitoshi Okazawa^1,2 (1. Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, 2. Center for Brain Integration Research)

Keywords:Alzheimer’s disease, DNA damage repair, Senescence, TRIAD necrosis