[3P] 63 Depressive and Bipolar disorders

[3P-255] (R)-ketamine improves depressive-like behaviors and social cognitive deficits by restoring neural activity of the anterior insular cortex in social isolation-induced model of depression

*Rei Yokoyama^1,2, Yukio Ago², Hisato Igarashi¹, Momoko Higuchi¹, Masato Tanuma¹, Yuto Shimazaki¹, Kaoru Seiriki¹, Misuzu Hayashida¹, Shun Yamaguchi^3,4, Hirokazu Tanaka⁵, Takanobu Nakazawa⁶, Kenji Hashimoto⁷, Atsushi Kasai^1,8, Hitoshi Hashimoto^1,9,10,11,12 (1. Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., Osaka, Japan, 2. Dept. Cell. Mol. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ., Hiroshima, Japan, 3. Dept. Morph. Neurosci., Grad. Sch. Med., Gifu Univ., Gifu, Japan, 4. Ctr. One Med. Innov. Transl. Res., Inst. Adv. Study, Gifu Univ., Gifu, Japan, 5. Fac. Info. Technol., Tokyo City Univ., Tokyo, Japan, 6. Dept. Biosci., Tokyo Univ. Agri., Tokyo, Japan, 7. Div. Clin. Neurosci., Chiba Univ. Ctr. Forensic. Mental Hlth., Chiba, Japan, 8. Sys. Brain Sci. Project, Drug Innov. Ctr., Grad. Sch. Pharmaceut. Sci., Osaka Univ., Osaka, Japan, 9. Mol. Res. Ctr. Children’s Mental Dev., United Grad. Sch. Child Dev., Osaka Univ., Osaka, Japan, 10. Inst. Datability Sci., Osaka Univ., Osaka, Japan, 11. Inst. Open Transdiscip. Res. Initiatives, Osaka Univ., Osaka, Japan, 12. Dep. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ., Osaka, Japan)

Keywords:Depression , Ketamine, (R)-ketamine, Social isolation