[1P] Alzheimer's Disease and Dementia

[1P-212] Reduced density of noradrenergic fibers without prominent neuron loss or tau pathology in the locus coeruleus in App knock-in mouse models of Aβ amyloidosis

*Yasufumi Sakakibara¹, Kyoko Ibaraki¹, Kimi Takei¹, Takashi Saito², Takaomi C Saido³, Michiko Sekiya^1,4, Koichi M Iijima^1,4 (1.Dept. of Alzheimer's Disease Research, National Center for Geriatrics and Gerontology, Aichi, Japan, 2.Dept. of Neurocognitive Sci., Nagoya City Univ. Grad. Sch. Med. Sci., Aichi, Japan, 3.Lab. for Proteolytic Neurosci., RIKEN CBS, Saitama, Japan, 4.Dept. of Experimental Gerontology, Nagoya City Univ. Grad. Sch. Pharm. Sci., Aichi, Japan)