Symposium

[S06] The frontier of medicinal plant chemical science

Sat. Mar 26, 2022 9:30 AM - 11:30 AM [Room Q] Shirotori Hall (North) (Bldg. 4: 1F)

Organizer: Takayoshi Awakawa (Grad. Sch. Pharm., The Univ. of Tokyo)

Recently, tremendous technological innovations related to life science have led to diverse new-generation-studies and a paradigm shift in various medicinal research fields. This innovation substantially changed research style of biosynthetic study and natural product discovery. The new starting point is "genome". In this background, natural products research is advancing from simply exploiting beneficial natural products, to designing new biosynthetic enzyme machinery for producing unnatural compounds. The cutting-edge researches in the natural product biosynthetic field have attracted the interest of pharmaceutical companies, and natural products have once again been revived as a key player of drug discovery scene. In this symposium, the five authorized Japanese scientists, whose backgrounds are natural product biosynthesis, metabolome, structural biology, and mechanistic enzymology, will present their original researches with their unique concepts on natural product-based drug development. We welcome a wide range of academic and industrial scientists in pharmaceutical sciences to discuss multiple perspectives on creating a roadmap for drug seed development with future biomolecule redesign.

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はじめに：淡川孝義（東大院薬） (9:30 AM - 9:45 AM)

9:45 AM - 10:05 AM

[S06-1] Elucidation of the biosynthetic pathway of solanoeclepin A exhibiting cyst nematode hatching inducer

○Kenji Watanabe¹ (1. Dept. Pharm., Univ. Shizuoka)

10:05 AM - 10:25 AM

[S06-2] Control of structural diversity and biological activity of steroidal glycoalkaloids by evolution of dioxygenases in Solanaceae

○Masaharu Mizutani¹ (1. Grad. School of Agric. Sci., Kobe Univ.)

10:25 AM - 10:45 AM

[S06-3] Structural biology of plant steroids biosynthesis and metabolic detoxification

Asami Miyazaki¹, Keisuke Fujiyama², Tomoya Hino², Yusuke Sato², Hyoung Jae Lee³, Ryota Akiyama³, Jumpei Kato³, Masaharu Mizutani³, Mitsuo Shoji⁴, Yasuteru Shigeta⁴, Bunta Watanabe⁵, ○Shingo Nagano² (1. Grad. Schl. Sust. Sci., Tottori Univ., 2. Grad. Schl. Eng., Tottori Univ., 3. Grad. Schl. Agri. Sci., Kobe Univ., 4. Cent. Comput. Sci., Tsukuba Univ., 5. Inst. Chem. Res., Kyoto Univ.)

10:45 AM - 11:05 AM

[S06-4] Mechanistic enzymology of the medicinal tropane alkaloid biosynthesis

○Richiro Ushimaru^1,2 (1. Grad. Sch. Pharm. Sci., Univ. Tokyo, 2. Dept. Chem, UT Austin)

11:05 AM - 11:25 AM

[S06-5] Biosynthetic study on plant alkaloids based on genomic information

○Mami Yamazaki¹ (1. Grad. Scl. Pharm. Sci, Chiba Univ.)

終わりに：淡川孝義（東大院薬） (11:25 AM - 11:30 AM)

Session information