オーガナイザー挨拶:関水 和久(帝京大薬) (1:30 PM - 1:35 PM)
Session information
Symposium
[S12] The forefront of drug discovery utilizing silkworms - Application for production of human biologics and disease models
Sat. Mar 26, 2022 1:30 PM - 3:30 PM [Room Q] Shirotori Hall (North) (Bldg. 4: 1F)
Organizer: Kazuhisa Sekimizu (Sch. Pharma-Sci., Teikyo Univ.), Kouji Itou (Grad. Sch. Pharmaceut. Sci., Tokushima Univ.)
Silkworm is a traditionally domesticated and sustainable insect for the industrial production of silk. Based on the remarkable ability of silkworms to overproduce silk proteins in silk glands and recent transgenic technology, gene-manufacturing (GM) silkworm strains have been developed to produce large amounts of drug substances for antibody pharmaceuticals and enzyme replacement therapy at a lower cost. Also, silkworms can be utilized for drug screening and efficacy evaluation due to the similarity in pharmacokinetics and drug response between humans and silkworms. In addition, silkworms, out of a target of animal welfare, are expected as substitution models for animal experiments. In this symposium, we introduce the recent advance in developing GM-silkworm overproducing glycoproteins available for biomedicine as GMP-grade pharmaceutical base materials. The safety and efficacy of glycol-engineered human lysosomal enzymes (CTSA and IDUA) for the disease model animals with the genetic enzyme deficiency will be presented. Furthermore, an application case of silkworms as human disease model reflecting cytokine storm pathology will be introduced.
1:35 PM - 1:55 PM
Ken-ichiro Tatematsu1, Megumi Sumitani1, Mitsuru Sato1, Masahiro Kusumoto1, Katsura Kojima1, Ryusei Izumi1,2, Hiroki Sakai1, Keiro Uchino1, Shuichiro Tomita1, Tetsuya Iizuka1, Toshiki Tamura3, ○Hideki Sezutsu1,2 (1. NARO, 2. Grad. Sch. Front. Sci., Univ. Tokyo, 3. Silk Sci. Tech. Res. Inst.)
1:55 PM - 2:15 PM
○Seiki Yageta1, Masahiro Tomita1 (1. IBL)
2:15 PM - 2:35 PM
○Kohji Itoh1, So-ichiro Nishioka1, Chika Shinoda1, Yoshie Takeuchi2, Jun Tsukimoto1, Yuya Sasai1, Takao Oishi3, Satomi Nadanaka4, Hiroshi Kitagawa4, Akira Harazono5, Akiko Ishii5, Isao Kobayashi6, Megumi Sumitani6, Ken-ichiro Tatematsu6, Hideki Sezutsu6 (1. Grad. Sch. Pharmaceut. Sci., Tokushima Univ., 2. Facult. Pharmaceut. Sci., Tokushima Univ., 3. Primate Res. Inst., Kyoto Univ., 4. Kobe Pharmaceut. Univ., 5. NIHS, 6. NARO)
2:35 PM - 2:55 PM
○Takao Oishi1, Akihisa Kaneko1, Takako Miyabe-Nishiwaki1, Kohji Itoh2 (1. Primate Res. Inst., Kyoto Univ., 2. Grad. Sch. Pharmaceut. Sci., Tokushima Univ.)
2:55 PM - 3:15 PM
○Atsushi Miyashita1, Kazuhisa Sekimizu2 (1. Inst. Med. Mycol., Teikyo Univ., 2. Sch. Pharma-Sci., Teikyo Univ.)
総合討論・総括:伊藤 孝司(徳島大院医歯薬) (3:15 PM - 3:30 PM)