[S32] Foldamers: The future pioneered by structural diversity

Sun. Mar 27, 2022 4:00 PM - 6:00 PM [Room B] Conference Room 131+132 (Bldg. 1: 3F)

Organizer: Takashi Misawa (NIHS), Mizuki Watanabe (Faculty of Pharm. Sci., Hokkaido Univ.)

"Foldamer" is an artificial oligomeric molecule with a regular secondary or tertiary structure consisting a low molecular unit. To date, a variety of foldamers has been developed, and is expected as new functional materials because of its unique structural properties. Foldamer was vigorously studied mainly in the field of macromolecular chemistry and engineering, whereas, in the field of pharmaceutical sciences, it has not been well known. However, foldamers can be attractive molecules even in this field because they can be chemically synthesized like low-molecular-weight compounds, and these molecules can have multipoint molecular recognition, which is difficult for low-molecular-weight compounds. Foldamers can have potential not only as tools for chemical biology study but also as drug candidates that target protein–protein interactions. (Review: Nat. Rev. Drug Discov. 2021, 20, 309)).
In this symposium, we would like to discuss recent advances of foldamer research: the design of the monomer molecules constituting the foldamer, and the sequence, the conformation, and the functions of the foldamers. We would also talk about the application to foldamers in drug discovery, which are expected to become the modality of the next-generation medium-sized molecular drugs.

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趣旨説明：三澤隆史（国立衛研） (4:00 PM - 4:02 PM)

4:02 PM - 4:25 PM

[S32-1] Synthesis and application of helical peptide foldamer using α,α-disubstituted α-amino acids

○Atsushi Ueda¹ (1. Grad. Sch. Biomed. Sci., Nagasaki Univ.)

4:25 PM - 4:48 PM

[S32-2] Construction of unique peptide nanostructures via metal-induced folding and assembly

○Tomohisa Sawada^1,2 (1. Sch. Eng. Univ. of Tokyo, 2. JST-PRESTO)

4:48 PM - 5:11 PM

[S32-3] Development of novel peptide foldamers based on cyclopropane amino acids

○Mizuki Watanabe¹ (1. Faculty of Pharm. Sci., Hokkaido Univ.)

5:11 PM - 5:34 PM

[S32-4] Controlling of Peptide Secondary Structures by Alkene Dipeptide Isosteres

○Tetsuo Narumi¹ (1. Grad. Sch. Integ. Sci. Tech., Shizuoka Univ.)

5:34 PM - 5:57 PM

[S32-5] Peptide-stapling enabled by oxidation of S-protected cysteine derivatives

○Akira Otaka¹ (1. Grad. School Pharm. Sci., Tokushima Univ.)

総括：渡邉瑞貴（北大院薬） (5:57 PM - 6:00 PM)