[27I-pm] Genetic drug delivery system-1

Sun. Mar 27, 2022 3:54 PM - 4:54 PM [Room I] Conference Room 222 (Bldg. 2: 2F)

Chair: Akihiro Kishimura

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3:54 PM - 4:06 PM

[27I-pm12] Controlling size of lipid nanoparticles using microfluidic device and its application for in vivo RNA delivery

○Yusuke Sato¹, Kento Okuda¹, Kazuki Iwakawa¹, Kosuke Sasaki¹, Hideyoshi Harashima¹ (1. Fac. Pharm. Sci., Hokkaido Univ.)

4:06 PM - 4:18 PM

[27I-pm13S] Development of Nose-to-Brain mRNA Delivery Technology Targeting the Brain

○Shoya Fujita¹, Hiroki Tanaka¹, Yu Sakurai², Yuta Nakai⁴, Kota Tange⁴, Takanori Kanazawa³, Hidetaka Akita¹ (1. Grad. Sch. Pharm. Sci., Chiba Univ., 2. Grad. Sch. Pharm. Sci., Tohoku Univ., 3. Grad. Sch. Pharm. Sci., shizuoka Univ., 4. NOF CORPORATION)

4:18 PM - 4:30 PM

[27I-pm14S] Effect of cholesterol content of lipid nanoparticles on protein expression distribution in intramuscular administration

○Maho Kawaguchi¹, Akari Ono², Mariko Kamiya¹, Shusaku Mizukami³, Hidefumi Mukai¹, Shigeru Kawakami¹ (1. Grad. Sch. Pharm. Sci., Nagasaki Univ., 2. Sch. Pharm. Sci., Nagasaki Univ., 3. Inst. Trop. Med., Nagasaki Univ.)

4:30 PM - 4:42 PM

[27I-pm15S] Effect of PEG anchor in PEGylation of folate-modified siRNA lipoplexes on gene silencing effect and siRNA biodistribution

○Min Tang¹, Sho Sakasai¹, Hiraku Onishi², Kumi Kawano¹, Yoshiyuki Hattori¹ (1. Mol Pharm, Hoshi Univ, 2. Drug Deliv Res, Hoshi Univ)

4:42 PM - 4:54 PM

[27I-pm16S] Development of Cas9 RNP delivery system comprising Tannic acid and Phenylboronic acid-conjugated polymers

○Takumi Matsuo^1,2, Yuto Honda^1,2, Takahiro Nomoto^1,2, Makoto Matsui², Yutaka Miura^1,2, Nobuhiro Nishiyama^1,2 (1. Dept. of Life Sci. and Tech., Tokyo Tech. , 2. Lab. for Chem. and Life Sci., Tokyo Tech.)

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