オーガナイザー挨拶：米田 誠治（鈴鹿医療大薬） (9:30 AM - 9:35 AM)
Session information
Symposium
[S22] "Unconventional" drug-discovery research using platinum group metals
Sun. Mar 27, 2022 9:30 AM - 11:30 AM [Room K] Conference Room 224 (Bldg. 2: 2F)
Organizer: Seiji Komeda (Fac. of Pharm. Sci., Suzuka Univ. Med. Sci.), Tsunehiko Higuchi (Grad. Sch. Pharm., Nagoya City Univ.)
Even now, more than 40 years after the clinical introduction of cisplatin, platinum-based drugs are still used in chemotherapy for various solid tumors. All platinum-based drugs are electrically neutral cis-type mononuclear platinum(II) complexes, and if the molecular design is performed using the same basic structure, a platinum complex exhibiting an effective antitumor efficacy can be obtained. However, in recent years, with the aim of reducing side effects and overcoming cross resistance to platinum-based drugs, platinum complexes with different basic structure from platinum-based drugs, or platinum group elements other than platinum (ruthenium, rhodium, palladium, osmium, iridium) is being used for "unconventional" drug-discovery research. Since a metal complex of a platinum group element is not easily hydrolyzed, it can bind to a target biomolecule while maintaining a unique geometric structure peculiar to the metal complex in an aqueous solution. In addition, the introduction of a functional ligand enables drug discovery using an approach different from that of conventional platinum-based drugs. In this symposium, we will introduce the drug-discovery researches of cancer therapeutic agents and cancer diagnostic agents using platinum group elements, and discuss new developments in inorganic medicinal chemistry.
9:35 AM - 10:00 AM
○Shigenobu Yano1, Yasuhiro Funahashi2, Akihiro Nomoto3, Misaki Nakai4 (1. Kyousei Sci. Ctr., Nara Women's Univ., 2. Grad. Sch. Sci., Osaka Univ., 3. Grad. Sch. Eng., Osaka Pref. Univ., 4. Fac. Matl. & Bioeng., Kansai Univ.)
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10:00 AM - 10:25 AM
○Ye Zhang1, Guanying Li1, Xunwu Hu1, Pingping Nie2, Dingze Mang1, Shi Jiao2, Shijin Zhang1, Sona Rani Roy1, Sachie Yukawa1, Shunsuke Asahina3, Hiroaki Sugasawa4, William Cortes1, Zhaocai Zhou2 (1. Bioinspired Soft Matter Unit, Okinawa Inst. Sci. & Tech., 2. State Key Lab. Genetic Eng., Sch. Life Sci., Fudan Univ., 3. SM Application Group, JEOL Ltd., 4. Asylum Res., Oxford Instruments K.K.)
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10:25 AM - 10:50 AM
○Kazuhito Tanabe1 (1. Coll. Sci. & Eng., Aoyama Gakuin Univ.)
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10:50 AM - 11:15 AM
○Shin Aoki1,2,3 (1. Dept. Med. & Life Sci., Fac of Pharm. Sci., Tokyo Univ. of Sci., 2. Res. Inst. for Sci. & Tech. (RIST), Org. for Res. Adv., Tokyo Univ. of Sci., 3. Res. Inst. for Biomed. Sci. (RIBS), Org. for Res. Adv., Tokyo Univ. of Sci.)
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総括：樋口 恒彦（名市大院薬） (11:15 AM - 11:30 AM)