[27L-am] Gastrointestinal absorption-1

Sun. Mar 27, 2022 9:30 AM - 10:42 AM [Room L] Conference Room 231 (Bldg. 2: 3F)

Chair: Yukio Kato

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9:30 AM - 9:42 AM

[27L-am01S] Analysis of intestinal absorption enhancing mechanisms by sodium methyl lauroyl taurate (LMT), a novel absorption enhancer - Effect of LMT on membrane fluidity, membrane resistance and expression level of tight junction related protein -

○Shogo Ueda¹, Minori Hosokawa¹, Hiroki Ukai¹, Masaki Morishita¹, Hidemasa Katsumi¹, Akira Yamamoto¹ (1. Kyoto Pharmaceutical University)

9:42 AM - 9:54 AM

[27L-am02S] Olmesartan is converted into a substrate of OATP2B1 by Medoxomil modification through the prodrug approach

○Naomi Fukazawa¹, Saki Noguchi¹, Tomohiro Nishimura¹, Masatoshi Tomi¹ (1. Division of Pharmaceutics, Faculty of Pharmacy, Keio University)

9:54 AM - 10:06 AM

[27L-am03S] Quantitative analysis of the impact of membrane permeability on gastrointestinal first-pass metabolism of drugs

○Yugo Yasugi¹, Yoshiyuki Shirasaka¹, Satoru Suzuki¹, Ikumi Tamai¹ (1. Fac. Pharm., Kanazawa Univ.)

10:06 AM - 10:18 AM

[27L-am04S] Investigation of in vivo behavior of extracellular vesicles (EV) with different sizes after administration into gastrointestinal tract

○Yuki Kobayashi¹, Momoko Naiki¹, Ayane Yabuta¹, Yuki Takahashi¹, Yoshinobu Takakura¹ (1. Grad. Sch. Pharm. Sci., Kyoto Univ.)

10:18 AM - 10:30 AM

[27L-am05S] Lysophosphatidylcholine-based liposome to improve nutraceutical properties of astaxanthin

○Antara Ghosh¹, Yui Suzuki¹, Yasuhiko Mibe², Shingo Rikimura², Tomomi Komamoto², Koichi Kuromi ², Kohei Yamada¹, Hideyuki Sato¹, Satomi Onoue¹ (1. Laboratory of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka, 2. BioMedCore, Inc.)

10:30 AM - 10:42 AM

[27L-am06S] Evaluation of Oral Availability of P-gp and CYP3A Substrates by New Absorption Prediction Method Considering Drug Concentration in Intestinal Epithelial Cells

○Aoi Yoshitomo¹, Satoshi Asano^1,2, Shizuka Hozuki¹, Yuta Tamemoto¹, Yasuhiro Kazuki³, Hiromi Sato¹, Akihiro Hisaka¹ (1. Grad Sch of Pharm. Sci., Chiba Univ., 2. DMPK Res Dept, Teijin Pharma Limited., 3. Chromosome Engineering Res Ctr, Tottori Univ.)

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