[27S-pm] Structure-activity relationship-2

Sun. Mar 27, 2022 3:42 PM - 4:54 PM [Room S] Conference Room 431 (Bldg. 4: 3F)

Chair: Tasuku Hirayama

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3:42 PM - 3:54 PM

[27S-pm12S] Modulation of the PRC2 function by a methionine-selective chemical modification of histone mutants

○Moe Toyobe¹, Satoshi Ichikawa^1,2, Fumika Yakushiji^1,2 (1. Fac. Pharm. Sci., Hokkaido Univ., 2. GI-CoRE, Hokkaido Univ.)

3:54 PM - 4:06 PM

[27S-pm13S] Structure activity relationship of LSD1 inhibition and stereochemistry of 2-phenylcyclopropylamine (PCPA) derivatives

○Ayane Shiobara¹, Ryo Tabusa¹, Shunsuke Fukasawa¹, Tomoko Hashimoto¹, Shun Hashimoto¹, Osamu Ohno¹, Hideaki Niwa², Shin Sato², Takashi Umehara², Kenji Matsuno¹ (1. School of Advanced Engineering, Kogakuin University, 2. RIKEN Center for Biosystems Dynamics Research)

4:06 PM - 4:18 PM

[27S-pm14S] Synthesis of DAG-lactone derivatives for cure of HIV infectious diseases

○Takahiro Ishii¹, Takuya Kobayakawa¹, Kouki Matsuda², Kohei Tsuji¹, Kazuhisa Yoshimura³, Hiroaki Mitsuya^2,4, Kenji Maeda², Hirokazu Tamamura¹ (1. Inst. Biomater. Bioeng., Tokyo Med. Dent. Univ., 2. Natl. Cnr. Glob. Health Med. Res. Inst., 3. Tokyo Metro. Inst. Pub. Health, 4. Natl. Cancer Inst., Natl. Inst. Health)

4:18 PM - 4:30 PM

[27S-pm15S] A study on selective inhibitors of bacterial MATE-type transporters responsible for multidrug resistance

○Susumu Shinya¹, Kentaro Kawai¹, Naoki Kobayashi², Yukiko Karuo¹, Atsushi Tarui¹, Kazuyuki Sato¹, Masato Otsuka¹, Masaaki Omote¹ (1. Fac. Pharm. Sci., Setsunan Univ., 2. Fac. Agric., Setsunan Univ.)

4:30 PM - 4:42 PM

[27S-pm16] Structure-activity relationship study of P1’ site structure of hydroxyethylamine-type BACE1 inhibitors

○Kazuya Kobayashi¹, Takuya Otani¹, Syun Ando¹, Momoka Kawakita¹, Katsuyasu Ishizawa¹, Risa Iseki¹, Taishi Kitajima¹, Naoka Shindo¹, Kouta Okawa¹, Kouta Ueda¹, Yasunao Hattori¹, Kenichi Akaji¹ (1. Kyoto Pharm. Univ.)

4:42 PM - 4:54 PM

[27S-pm17S] Synthesis and structure-activity relationship study of stereoisomers of tryptolinamide as phosphofructokinase-1 inhibitor

○Ryo Kakehi¹, Hiroki Kobayashi^2,3, Haruna Nishimura², Minoru Yoshida^2,4, Yasuo Nagaoka¹, Takaaki Sumiyoshi¹ (1. Dept. Life Sci. & Tech., Kansai Univ., 2. RIKEN CSRS, 3. Tokyo Univ. Pharm. Life Sci., 4. Dept Biotechnol, Univ. Tokyo)

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