[28B-pm] Drug design-5/Synthetic compounds in drug discovery/Others

Mon. Mar 28, 2022 4:54 PM - 5:54 PM [Room B] Conference Room 131+132 (Bldg. 1: 3F)

Chair: Yuji Sumii

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4:54 PM - 5:06 PM

[28B-pm07] SAR study on α-methylene cyclopentanone with NF-kB inhibitory activity

○Aki Kohyama^1,2, Aya Shuichi², Zhou Yue², Hiroaki Sakurai², Yuji Matsuya² (1. Grad. Sch. Pharm. Sci., Tohoku University, 2. Fac. Pharm. Sci., Toyama University)

5:06 PM - 5:18 PM

[28B-pm08S] Effect of byproducts generated during the synthesis process of nucleic acid drugs on the binding affinity to target mRNA.

○Tomoka Akita¹, Junji Kawakami¹ (1. Konan University, FIRST)

5:18 PM - 5:30 PM

[28B-pm09S] Rapid and Efficient Synthesis of PROTACs by Solid-Phase Synthesis

○Hanqiao Xu^1,2, Takashi Kurohara², Hidetomo Yokoo³, Genichiro Tsuji², Norihito Shibata², Nobumichi Ohoka², Takao Inoue², Yosuke Demizu^1,2 (1. Grad. Sch. of Med. Life Sci., Yokohama City Univ., 2. Natl. Inst. of Health Sci., 3. Kyoto Prefectural Univ. of Med.)

5:30 PM - 5:42 PM

[28B-pm10] Development of Anti-SARS-CoV-2 Drug Based on Amodiaquine

○Tomohiro Tanaka¹, Kenta Yokoi¹, Hidetoshi Sato¹, Tomoe Morita¹, Azusa Kanbe¹, Yayoi Yoshimura¹, Mika Okamoto², Masaaki Toyama², Masanori Baba², Shin Aoki^1,3 (1. Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2. Joint Research Center for Human Retrovirus Infection, Kagoshima University, 3. Research Institute for Science and Technology, Tokyo University of Science)

5:42 PM - 5:54 PM

[28B-pm11S] Development of process synthesis method for retinoid X receptor agonist NEt-3IB and examination of its crystal forms

○Yuta Takamura¹, Ken-ichi Morishita¹, Shota Kikuzawa¹, Masaki Watanabe¹, Michiko Fujihara¹, Hiromi Ohta², Hiroki Kakuta¹ (1. Grad. Sch. Med., Dent. Pharm. Sci., Okayama Univ., 2. Adv. Sci. Res. Center, Okayama Univ.)

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