[28S-pm] Organic Chemistry (Others-5)

Mon. Mar 28, 2022 4:42 PM - 5:54 PM [Room S] Conference Room 431 (Bldg. 4: 3F)

Chair: Yasufumi Fuchi

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4:42 PM - 4:54 PM

[28S-pm17] Membrane Permeable Oligonucleotide as a Delivery Platform for Nucleotide Therapeutics

○Hayase Hakariya¹, Haruka Hiraoka¹, Zhaoma Shu¹, Noriaki Matsubara¹, Fangjie Lyu¹, Masahito Inagaki¹, Li Zhenmin¹, Soo Steve¹, Yasuaki Kimura¹, Hiroshi Abe¹ (1. Grad. Sch. Sci., Nagoya Univ.)

4:54 PM - 5:06 PM

[28S-pm18S] Enhancement of target specificity of siRNA by a novel 2′-modified nucleoside analog

○Rintaro Baba¹, Kohei Nomura¹, Naoko Abe¹, Seongin An⁴, Yoshiaki KOBAYASHI⁵, Kumiko Tei^4,5, Fumitaka Hashiya¹, Yasuaki Kimura¹, Hiroshi Abe^1,2,3 (1. Grad. Sch. Sci., Nagoya Univ, 2. JST-CREST, 3. iGCORE, 4. Grad. Sch. Fro. Sci., Tokyo Univ., 5. Grad. Sch. Sci., Tokyo Univ.)

5:06 PM - 5:18 PM

[28S-pm19] Development of fluorophosphoramidate as a new biocompatibly transformable functional group and its application as a phosphate prodrug for nucleoside analogs

○Yasuaki Kimura¹, Yuki Yoshida¹, Fumiaki Tomoike^1,5, Fumitaka Hashiya¹, Shuto Hirota², Yuriko Saiki², Akira Horii², Akiyoshi Hirayama⁶, Tomoyoshi Soga⁶, Hiroshi Abe^1,3,4 (1. Graduate School of Science, Nagoya University, 2. Graduate School of Medicine, Tohoku University , 3. JST CREST, 4. Institute for Glyco-core Research, 5. Department of Life Science, Gakushuin University, 6. Institute for Advanced Biosciences, Keio University)

5:18 PM - 5:30 PM

[28S-pm20S] Enzymatic synthesis of 2'-MOE oligonucleotide for aptamer therapeutics

○Kenta Ishida^1,2, Yuuya Kasahara^1,2, Hidekazu Hoshino², Yoshihiro Yoneda², Satoshi Obika^1,2 (1. Grad. Sch. Pharm. Sci., Osaka Univ., 2. NIBIOHN)

5:30 PM - 5:42 PM

[28S-pm21] Chemical mRNA synthesis using an efficient chemical capping reaction

○Naoko Abe¹, Akihiro Imaeda¹, Yasuaki Kimura¹, Fumitaka Hashiya¹, Satoshi Uchida², Hiroshi Abe¹ (1. Graduate School of Science, Nagoya University, 2. Graduate School of Medicine, Kyoto Prefectural University of Medicine)

5:42 PM - 5:54 PM

[28S-pm22] Novel Oligonucleotides Strand Cleavage Reaction Induced by Precious Metal Nanoparticles for Long Oligonucleotides Synthesis

○Masahito Inagaki¹, Haruka Hiraoka¹, Mikiya Kase¹, Fumitaka Hashiya², Naoko Abe¹, Yasuaki Kimura¹, Hiroshi Abe^1,3,4 (1. Grad. Sch. Sci., Nagoya Univ., 2. Research Center for Material Science, Nagoya Univ., 3. CREST, Japan Science and Technology Agency, 4. Institute for Glyco-core Research (iGCORE))

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