[D-2] Biosensor, Chips and Microfluidic Devices for Cell Functions

[D-2-03] Fabrication of UCNP (Upconversion Nanoparticle) Disk Device for Non-Invasive Optical Stimulation Therapy of Organ Diseases

〇Shimon - Suzuki¹, Hisashi - Kino², Takafumi - Fukushima¹, Tetsu - Tanaka^1,2 (1. Department of Mechanical Systems Engineering, Graduate School of Engineering, Tohoku University (Japan), 2. Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University (Japan))

Presentation style: Online

https://doi.org/10.7567/SSDM.2022.D-2-03

Recently, a method of optical stimulation with an optical fiber by introducing a light-sensitive protein into the vagus nerve leading to the pancreas has been investigated as a treatment for diabetes mellitus. However, the optical fiber-based method has the problem of stimulating organs other than the target organ. Therefore, in this study, we proposed a non-invasive UCNP disk device using upconversion nanoparticles (UCNPs); UCNPs were mixed with a photosensitive resin SU-8 and formed into a disc shape to develop the UCNP disk device. This disc device can be introduced into the whole organ through the pancreatic duct, etc., and non-invasive optical stimulation of specific organs is possible by wirelessly emitting UCNPs. In this study, the UCNP disk device was evaluated by shape evaluation, luminescence test, and In-vitro experiment.