[D-2] Biosensor, Chips and Microfluidic Devices for Cell Functions

[D-2-06] A 3D-MICROFLUIDIC DRUG TESTING PLATFORM INFLUENCED BY RETICULATE VENATION OF DICOTS

〇Madhushree Poddar¹, Yu-de Chu², Chau-Ting Yeh², Cheng-Hsien Liu¹ (1. National Tsing Hua University (Taiwan), 2. Chang Gung Memorial Hospital (Taiwan))

Presentation style: Online

https://doi.org/10.7567/SSDM.2022.D-2-06

Three-dimensional (3D) tissue models replicating liver architectures and functions are increasingly being needed for regenerative medicine. We present here a simple yet unique polydimethylsiloxane (PDMS) microfluidic chip for an easy setup of a 3D co-culture mimicking liver tumor microenvironment for drug testing. We aim to provide stable culture and open a pathway for various biological applications like drug testing. This chip contains two co-culture systems counterfeiting tumor microenvironment, including individual control groups in a gelatin methacryloyl (GelMA) hydrogel-based matrix applicable for drug testing.