[D-3] Advanced Technologies for Bio- and Chemical Sensing

[D-3-06] Detection of Lysophosphatidylcholine, a Sepsis Biomarker, from Complex Solution and Plasma, in Few Minutes, using Silanized Porous Silicon Surfaces and Desorption Ionization on Silicon Mass Spectrometry.

〇Antonin Lavigne¹, Benoit Gilquin², Vincent Jousseaume², Marc Veillerot², Thomas Géhin³, Céline Chevalier³, Cécile Jamois³, Yann Chevolot³, Magali Phaner-Goutorbe¹, Christelle Yeromonahos¹ (1. Univ. Lyon, Ecole Centrale de Lyon (France), 2. Univ. Grenoble Alpes, CEA Leti (France), 3. Univ. Lyon, CNRS (France))

Presentation style: Online

https://doi.org/10.7567/SSDM.2022.D-3-06

In the present study, we propose a tool for Lyso-PC trapping, from plasma, based on porous silanized silicon surfaces and compatible with Desorption Ionization on Silicon Mass Spectrometry (DIOS-MS) detection. Results show that by tuning the chemical nature of the silane monolayer, the Lyso-PC MS detection signal can be im-proved enough to overcome the use of an organic matrix and to allow direct detection in plasma samples, without any pre-treatment steps.