[2P-279] Androgen dependent intracellular signaling in proliferation of prostate cancer cells.

^○Watanabe Keisuke W.¹, Watanabe Kenta W.², Hirata Michiko H.¹, Miyaura Chisato M.^1,2, Inada Masaki I.^1,2 (1.Dept. of Biotech. and Life Sci., Tokyo Univ. of Agri. and Tech., 2.Institute of Global Innovation Research, Tokyo Univ. of Agri. and Tech.)

The 91th Annual Meeting of JBS

[2P-280] Resveratrol activates p53 pathway by suppressing the expression of Hsp90

^○Takamura Kana¹, Endo Hiroshi¹, Kimura Yoshimi², Yano Mihiro¹ (1.Division of Nutrition, Graduate School of Human Culture, University of Shiga Pref., 2.Department of Nutrition, School of Human Culture, University of Shiga Pref.)

The 91th Annual Meeting of JBS

[2P-281] Functions of tumor suppressor gene Mob1 in the uterus

^○Aono Yukari¹, Nishio Miki¹, To Yoko², Maehama Tomohiko¹, Kiyono Toru⁴, Katabuchi Hidetaka², Tashiro Hironori³, Suzuki Akira¹ (1.Div. of Mol. and Cell. Biol., Grad. Sch. of Med., Kobe Univ., 2.Dept. of Obst. and Gynecol., Faculty of Life Sci., Kumamoto Univ., 3.Dept. of Maternal-Newborn Nursing, Sch. of Health Sci., Kumamoto Univ., 4.Div. of Carcinogenesis and Cancer Prevention, Natl. Cancer Res. Inst.)

The 91th Annual Meeting of JBS

[2P-282] Multiple effects of gamabufotalin on human glioblastoma U-87 cells

^○Yuan Bo, Shimada Ryota, Xu Kang, Hayashi Hideki, Takagi Norio (Department of Applied Biochemistry, Tokyo University of Pharmacy & Life Sciences)

The 91th Annual Meeting of JBS

[2P-283] Suppression of tumorigenicity for mesothelioma: a novel approach to inhibit function of YAP

^○Nakano Naoko¹, Kawamoto Rie¹, Ishikawa Ryo¹, Sano Keigo¹, Fukuda Kazuo², Shouda Takuji³, Hattori Takayuki⁴, Kurihara Masaaki³, Yamazaki Ryu², Nakane Takahisa⁵, Okamoto Iwao², Naito Mikihiko⁴, Itoh Susumu¹ (1.Laboratory of Biochemistry, Showa Pharmaceutical University, 2.Laboratory of Pharmaceutical Organic Chemistry, Showa Pharmaceutical University, 3.Division of Organic Chemistry, National Institute of Health Sciences, 4.Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, 5.Laboratory of Natural Products Chemistry, Showa Pharmaceutical University)

The 91th Annual Meeting of JBS

[2P-284] Contributions of apoptosis induction and JNK activation to enhanced cytotoxicity of arsenite and tetrandrine in human breast cancer cell line MDA-MB-231

^○Yu Bowen^1,2, Yuan Bo¹, Kiyomi Anna³, Tanaka Sachiko⁴, Hayashi Hideki¹, Sugiura Munetoshi³, Hirano Toshihiko⁴, Pei Xiaohua², Takagi Norio¹ (1.Department of Applied Biochemistry, Tokyo University of Pharmacy & Life Sciences, 2.Beijing University of Chinese Medicine Third Affiliated Hospital, 3.Department of Drug Safety and Risk Management, Tokyo University of Pharmacy & Life Sciences, 4.Department of Clinical Pharmacology, Tokyo University of Pharmacy & Life Sciences)

The 91th Annual Meeting of JBS

[2P-285] Establishment and epitope mapping of cancer-specific anti-canine podoplanin mAb

^○Furusawa Yoshikazu^1,2, Itai Shunsuke^1,3, Yamada Shinji¹, Kaneko Mika K.¹, Kato Yukinari¹ (1.Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Miyagi, Japan, 2.Zenoaq Resource Co.,Ltd., 3.Department of Oral and Maxillofacial surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University)

The 91th Annual Meeting of JBS

[2P-286] Tumor progression through Trop-2 phosphorylation

^○Mori Yugo, Akita Kaoru, Nakada Hiroshi (Dept. Mol. Biosci., Fac. Life Sci., Kyoto Sangyo Univ.)

The 91th Annual Meeting of JBS

[2P-287] ASK1 in endothelial cells contributes to lung metastasis

^○Furukawa Natsuki, Kamiyama Miki, Naguro Isao, Ichijo Hidenori (Cell signaling, Grad. Sch. Pharmaceut. Sci., UTokyo)

The 91th Annual Meeting of JBS

[2P-288] Mechanistic analysis of suppression of cell proliferation by a novel FXR-induced miRNA in colorectal cancer cells

^○Shimizu Seiki¹, Kubota Chiaki², Kawamura Yuki², Fujii Hiroshi^1,2,3 (1.Dept. of Biomed. & Eng., Grad. Sch. of Sci. & Technol., Shinshu Univ., 2.Dept. of Biotech., Grad. Sch. of Agr., Shinshu Univ, 3.Dep. of Interdisci. Genome Sci. & Cell Met., Inst. for Biomed. Sci. (IBS), Interdisci. Cluster for Cutting Edge Res. (ICCER)3, Shinshu Univ.)

The 91th Annual Meeting of JBS