[2P-329] Spine morphological analysis and transcriptome profiling in activated neurons expressing the immediate-early gene Arc during memory-related processes in the mouse hippocampus

^○Minatohara Keiichiro¹, Suzuki Yutaka², Sugano Sumio², Bito Haruhiko³, Okuno Hiroyuki¹ (1.Dept of Biochem and Mol Biology, Kagoshima Univ Grad Sch of Med and Dent Sci, 2.Univ of Tokyo Grad Sch of Front Sci;, 3.Dept of Neurochem, Univ of Tokyo Grad Sch of Med)

The 91th Annual Meeting of JBS

[2P-330] Characterization of the zebrafish glycine receptors

^○Ito Daishi¹, Hirata Hiromi^1,2 (1.Graduate School of Science and Engineering, Aoyama Gakuin University, 2.College of Science and Engineering, Aoyama Gakuin University)

The 91th Annual Meeting of JBS

[2P-331(2T13m-05)] miR-124a is regulated for normal neural function in the prefrontal cortex

^○Yamamoto Haruka¹, Kozuka Takashi¹, Omori Yoshihiro¹, Hikida Takatoshi², Furukawa Takahisa¹ (1.Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, 2.Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University)

The 91th Annual Meeting of JBS

[2P-332(2T13m-04)] The increment of membrane cholesterol aggravates endocytic disturbance, resulting in enhanced Aβ accumulation: mechanism underlying acceleration of Aβ pathology by type 2 diabetes mellitus

^○Kimura Nobuyuki¹, Takeuchi Shingo¹, Ueda Naoya¹, Suzuki Keiko¹, Shimozawa Nobuhiro², Yasutomi Yasuhiro² (1.Section of Cell Biol & Pathol., Dept. Alzheimer's Dis. Res., NCGG, 2.Tsukuba Primare Research Center, NIBIOHN)

The 91th Annual Meeting of JBS

[2P-333(2T13m-07)] Structural alterations of neurons in schizophrenia

^○Katana Sakura¹, Sato Nana¹, Takekoshi Susumu², Inomoto Chie², Nakamura Naoya², Arai Makoto³, Oshima Kenichi³, Itokawa Masanari³, Torii Youta⁴, Kushima Itaru⁴, Iritani Shuji⁴, Ozaki Norio⁴, Takeuchi Akihisa⁵, Uesugi Kentaro⁵, Terada Yasuko⁵, Suzuki Yoshio⁶, De Andrade Vincent⁷, De Carlo Francesco⁷, Saiga Rino¹, Mizutani Ryuta¹ (1.Sch. of Engineering, Tokai Univ., 2.Tokai Univ. Sch. of Medicine, 3.Tokyo Metropolitan Institute of Medical Sci., 4.Grad. Sch. of Medicine, Nagoya Univ., 5.JASRI/SPring-8, 6.Grad. Sch. of Frontier Sciences, Univ. of Tokyo, 7.Advanced Photon Source, Argonne National Lab.)

The 91th Annual Meeting of JBS

[2P-334(2T13m-08)] Structural optimization of aliphatic catechin derivatives enhancing Aβ-degrading enzyme neprilysin

^○Hori Yuma, Jiuchi Yuka, Watanabe Kaori, Ota Ryosuke, Takamiya Yuma, Yassen Asmaa Said Ali, Qian Hao, Hatta Daisuke, Shirotani Keiro, Tanaka Takashi, Iwata Nobuhisa (Graduate School of Biomedical Sciences, Nagasaki University, Japan)

The 91th Annual Meeting of JBS

[2P-335(2T13m-10)] In silico drug screening by using genome-wide association study (GWAS)-data repurposed a novel disease-modifying drug for Parkinson's disease

^○Uenaka Takeshi¹, Satake Wataru¹, CHA Pei-Chieng¹, Hayakawa Hideki², Baba Kousuke², Kobayashi Kazuhiro¹, Kanagawa Motoi¹, Okada Yukinori³, Mochizuki Hideki², Toda Tatsushi^1,4 (1.Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan, 2.Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan, 3.Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan, 4.Department of Neurology, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo)

The 91th Annual Meeting of JBS

[2P-336(2T13m-09)] The preventive approach for Alzheimer's disease based on the novel neprilysin regulator

^○Watamura Naoto¹, Kakiya Naomasa¹, Saito Takashi¹, Per Nilsson^1,2, Saido Takaomi¹ (1.Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2.Karolinska Institutet. Center for Alzheimer Research, Dept. of Neurobiology, Care Sciences and Society, Division for Neurogeriatrics.)

The 91th Annual Meeting of JBS

[2P-337] Localization of Stress-induced Phosphorylated Proteins in the Mouse Brain

^○Yamamori Saori, Mandai Kenji (Kitasato Univ. School of Medicine, Biochemistry)

The 91th Annual Meeting of JBS

[2P-338] Effects of Memantine on the Growth and Protein Profiles of Neuroblastoma Cells

^○Sato Masaaki¹, Sekiguchi Kiyoshi², Sato Toshiyuki¹, Tutiya Atsuhiro¹, Omoteyama Kazuki¹, Arito Mitsumi¹, Suematsu Naoya¹, Kato Tomohiro¹, Kurokawa Manae S.² (1.Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, 2.Disease Biomarker Analysis and Molecular Regulation, St. Marianna University Graduate School of Medicine)

The 91th Annual Meeting of JBS