[P-295] Expression of trypanosomal acetate:succinate CoA transferase is sufficient to develop resistance to the ATP synthase inhibitor Bedaquiline in Mycobacterium smegmatis

^○Bundutidi M.G.^1,2,3, Y. Ando⁴, Y. Matsuo^5,6, Y. Nakatani^5,7, H. Kiel^7,8, G. M. Cook^7,8, T. Sakura^3,5, S. Hamano^1,2, K. Hirayama⁵, K. Kita^5,9,10, D. K. Inaoka^3,5,9 (1.Grad Sch Biomed Sci, Nagasaki Uni(NU), 2.Dept Parasitol, Inst Trop Med (NEKKEN), NU, 3.Dept Mole Infect Dyn, NEKKEN, NU, 4.Dept Infectious Dis Cont, Fac of Med, Oita Uni, 5.Sch Trop Med Glob Heal, NU, 6.Grad Sch Life Sci, Kumamoto Uni, 7.Dept Micro Immun, Sch Biomed Sci, Uni Otago, New Zealand, 8.Maurice Wilkins Cent Mol Biodis, Uni Auckland, New Zealand, 9.Dept Biomed Chem, Grad Sch Med, Uni Tokyo, 10.Dept Host-Def Biochem, NEKKEN, NU)

The 94th Annual Meeting of JBS

[P-296] Synthesis and evaluation of naphthalenedicarboxylic acid derivatives that inhibit dinuclear metal enzymes

^○Ayumu K. Kobayashi¹, Sunnam K. Kim², Tsuyoshi F. Fukaminato², Yoshihiro Y. Yamaguchi³, Seiji K. Kurihara² (1.Graduate School of Science and Technology, Kumamoto University, 2.Fuculty of Advanced Science and Technology, Kumamoto University, 3.Environmental Safety Center, Kumamoto University)

The 94th Annual Meeting of JBS

[P-297] Effects of metal-ion binding to ribonuclease HI from Escherichia coli and the role of His124

^○Yumi Kitagawa¹, Zengwei Liao², Kosuke Morikawa³, Masayuki Oda² (1.Faculty Life Environ. Sci., Kyoto Pref. Univ., 2.Grad. Sch. Life Environ. Sci., Kyoto Pref. Univ., 3.Grad. Sch. Biostudies, Kyoto Univ.)

The 94th Annual Meeting of JBS

[P-298] The significance of cleavage of Calpain-1 by its isoform Calpain-2.

^○Fumiko Shinkai-Ouchi¹, Mayumi Shindo², Naoko Doi¹, Shoji Hata¹, Yasuko Ono¹ (1.Calpain PJ, Tokyko Metropolitan Insitute of Medical Science, 2.Center for Basic Technology Research, Tokyko Metropolitan Insitute of Medical Science)

The 94th Annual Meeting of JBS

[P-299] Molecular mechanism of the substrate specificity conversion of L-lysine α-oxidase from Trichoderma viride by point mutation.

^○Yuka Ueda¹, Ryota Matsuda¹, Masaya Saito², Takashi Tamura², Kenji Inagaki², Norihiro Takekawa¹, Katsumi Imada¹ (1.Grad. Sch. Sci., Osaka Univ., 2.Grad. Sch. Env. & Life Sci., Okayama Univ.)

The 94th Annual Meeting of JBS

[P-300(1T13a-01)] Reaction mechanism analysis based on crystal structure of L-methionine decarboxylase from Streptomyces

^○Atsushi Okawa¹, Tomoaki Inoue², Yuki Onoue², Tomoo Shiba², Junko Inagaki³, Takashi Tamura¹, Kenji Inagaki¹ (1.Grad. Sch. Environ. Life Sci., Okayama Univ., 2.Grad. Sch. Sci. Technol., Kyoto Inst. Technol., 3.Grad. Sch. Med. Dent. Pharm. Sci., Okayama Univ.)

The 94th Annual Meeting of JBS

[P-301] Suppressive mechanism of N-type glycosylation inhibitor for Aβ production

^○Takumi Fujii, Yasuomi Urano, Satoru Funamoto, Noriko Noguchi (Sys. Life Sci. Lab., Grad. Sch. Of Life & Med. Sci., Doshisha Univ)

The 94th Annual Meeting of JBS

[P-302(1T13a-02)] Analysis of archaeal cis-prenyltransferase via fusion of hetero-subunits

^○Arisa Nagasaka, Kitty Sompiyachoke, Tohru Yoshimura, Hisashi Hemmi (Department of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University)

The 94th Annual Meeting of JBS

[P-303(1T13a-05)] Identification of 3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives as novel selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

^○Hartuti Endah Dwi^1,2,3, Takaya Sakura^4,5, Mohammed S. O. Tagod⁵, Eri Yoshida⁴, Xinying Wang^5,6, Kota Mochizuki⁷, Rajib Acharjee^1,2, Fuyuki Tokumasu⁸, Mihoko Mori⁹, Danang Waluyo³, Kazuro Shiomi⁹, Tomoyoshi Nozaki⁶, Shinjiro Hamano^1,2 (1.Program for Nurturing Global Leaders in Tropical and Emerging Communicable Disease, Nagasaki University, 2.Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 3.Laboratory for Biotechnology, Agency for the Assessment and Application of Technology, Indonesia, 4.Department of Molecular Infection Dynamics, NEKKEN, Nagasaki University, 5.School of Tropical Medicine and Global Health, Nagasaki University, 6.Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7.Department of Immunogenetics, NEKKEN, Nagasaki University, 8.Department of Cellular Architecture Studies, NEKKEN, Nagasaki University, 9.Graduate School of Infection Control Sciences, Kitasato University, 10.Department of Host-Defense Biochemistry, NEKKEN, Nagasaki University)

The 94th Annual Meeting of JBS

[P-304] Biochemical studies of malate:quinone oxidoreductase from Toxoplasma gondii

^○Acharjee R¹, K. K. Talaam¹, E. D. Hartuti¹, Y. Matsuo², T. Sakura^2,3, B. M. Gloria¹, S. Hidano⁴, Y. Kido⁵, M. Mori⁶, K. Shiomi⁶, M. Sekijima⁷, T. Nozaki⁸, K. Umeda⁹, Kiyoshi Kita^5,6,10, Daniel Ken Inaoka^4,5,6 (1.Grad Sch Biomed Sci, Nagasaki Uni, 2.Sch Trop Med Glob Heal, Nagasaki Uni;, 3.Dept Mole Infect Dyn, Inst Trop Med, NEKKEN, Nagasaki Uni;, 4.Dept Immune Regu, The Res Cent Hepat Immunol, Nat Cent Glob Heal Med;, 5.Dept Para Res Cent Infectious Dis Sci, Grad Sch Med, Osaka City Uni;, 6.Grad Sch Infect Cont Sci, Kitasato Uni;, 7.Dept Adv Computa Drug Disc Unit, Tokyo Inst Tech;, 8.Dept Biomed Chem, Grad Sch Med, The Uni Tokyo;, 9.Res Unit Host Def, Nat Res Cent Proto Dis, Obihiro Uni Agri Vet Med, Hokkaido, 10.Dept Parasitol, Host-Def Biochem, NEKKEN, Nagasaki Uni.)

The 94th Annual Meeting of JBS