[P-745] DKK1-CKAP4 signaling and its potential as a therapeutic target in lung cancer

^○Akihiro Nagoya, Ryota Sada, Hirokazu Kimura, Hideki Yamamoto, Akira Kikuchi (Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University)

The 94th Annual Meeting of JBS

[P-746] Resistance mechanism to a cytotoxic oncometabolite

^○Takeshi Ueda, Akiyoshi Komuro, Hisayuki Amano, Masahiko Honda, Hitoshi Okada (Department of Biochemistry, Kindai University Faculty of Medicine, Japan)

The 94th Annual Meeting of JBS

[P-747] Tomato leaves extract containing tomatidine suppressed tumorigenesis in 85As2 cell induced syngeneic mouse model

^○Junya Fujimaki¹, Shigenobu Shiotani², Miki Nonaka³, Yasuhito Uezono³, Haruo Nukaya¹, Keiji Wakabayashi¹, Akihito Morita^1,4, Tomoki Sato^1,4, Shinji Miura^1,4 (1.Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 2.Tokai Bussan Co.,Ltd, 3.Department of Pain Control Research, The Jikei University School of Medicine, 4.School of Food and Nutritional Sciences, University of Shizuoka)

The 94th Annual Meeting of JBS

[P-748] Cooperation of HOXA9 and MYC in MLL leukemia

^○Ryo Miyamoto¹, Akinori Kanai², Hiroshi Okuda¹, Satoshi Takahashi¹, Toshiya Inaba², Akihiko Yokoyama¹ (1.Tsuruoka Metabolomics Laboratory, National Cancer Center, 2.Research Institute for Radiation Biology and Medicine, Hiroshima University)

The 94th Annual Meeting of JBS

[P-749(1T14e-04)] v-Src oncogenesis involves v-Src-induced mitotic defects

^○Yuji Nakayama, Masayoshi Ikeuchi, Ryuzaburo Yuki, Youhei Saito (Kyoto Pharmaceutical University)

The 94th Annual Meeting of JBS

[P-750(1T14e-05)] Significance of Src activation in tumor microenvironment

^○Kano Tomishima, Masato Okada, Shigeyuki Nada (Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University)

The 94th Annual Meeting of JBS

[P-751] Molecular mechanisms of selective poly(ADP-ribose)glycohydrolase inhibitor PDD00017273 resistance in human colorectal cancer HCT116 cells.

^○Kaede Tsuda¹, Chinatu Kurasaka¹, Yoko Ogino^1,2, Akira Sato¹ (1.Department of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science., 2.Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science.)

The 94th Annual Meeting of JBS

[P-752] Identification of 16 modifier loci post-K-ras mutation by QTL analysis using K-rasG12V mediated lung tumor mouse models.

^○Hiromitsu Saito, Noboru Suzuki (Department of Animal Functional Genomics of Advanced Science Research Promotion Center, Organization for the Promotion of Regional Innovation)

The 94th Annual Meeting of JBS

[P-753] The effect of Gb3 expressed in cancer cells against anticancer drug sensitivityGlobotriaosylceramide expression involves in the anticancer drug sensitivity of cancer cells

^○Yoshiaki Yagihashi, Shigeki Sugawara, Souta Kikuti, Takeo Tatuta, Masahiro Hosono (Div. of Cell Recognition, Tohoku Medical and Pharmaceutical University)

The 94th Annual Meeting of JBS

[P-754] Investigation of antitumor effect of Shufeng Jiedu on hepatoma cells.

^○Yoshinori Inagaki¹, Jufeng Xia¹, Tatsuo Sawakami¹, Peipei Song², Wei Tang², Kiyoshi Hasegawa¹ (1.Hepato-biliary-pancreatic Surg. Div., Dept. of Surg., Grad. Sch. of Med., Univ. of Tokyo, Tokyo, Japan, 2.National Center for Global Health and Medicine)

The 94th Annual Meeting of JBS