[2T16a-04（3P-332）] Different mitochondrial DNA heteroplasmy distributions at the single-cell level in patients with mitochondrial diseases

Atsuko Okazaki¹, Kazuhiro R. Nitta^1,2, Yukiko Yatsuka¹, ^〇Ayumu Sugiura¹, Masato Arao³, Masaru Shimura⁴, Tomohiro Ebihara⁴, Takanori Onuki⁴, Keiko Ichimoto⁴, Akira Ohtake^3,5,6, Kei Murayama⁴, Yasushi Okazaki^1,2 (1. Diagnostics and Therapeutics of Intractable Diseases, Juntendo University, Graduate School of Medicine, 2.Laboratory for Comprehensive Genomic Analysis, Center for Integrative Medical Sciences, RIKEN, 3.Department of Pediatrics, Saitama Medical University, 4.Department of Metabolism, Chiba Children's Hospital, 5.Center for Intractable Diseases, Saitama Medical University Hospital, 6.Department of Clinical Genomics, Saitama Medical University)

The 95th Annual Meeting of the Japanese Biochemical Society |Thu. Nov 10, 2022 1:50 PM - 2:00 PM

[2T16a-05（3P-333）] Molecular mechanisms of peliosis hepatitis associated with X-linked myotubular myopathy (XLMTM)

^〇Nobuyuki Shimizu¹, Hiroshi Shiraishi¹, Masanori Inoue², Kyoko Kiyota², Kenji Ihara², Toshikatsu Hanada¹ (1.Oita University Faculty of Medicine, Department of Cell Biology, 2.Oita University Faculty of Medicine, Department of Pediatrics)

The 95th Annual Meeting of the Japanese Biochemical Society |Thu. Nov 10, 2022 2:00 PM - 2:10 PM

[2T16a-06（1P-327）] Development of a more effective gene therapy drug for an inherited metabolic disease Galactosialidosis

^〇Mizuki Miyoshi ¹, Jun Tsukimoto¹, Yuto Horii¹, Yoshie Takeuchi², Nijiho Kamori², Rin Fukuike¹, Michiko Kino³, Naozumi Ishimaru³, Kohji Itoh^1,2 (1.Graduate School of Pharmaceutical Sciences, Tokushima University, 2.Faculty of Pharmacy, Tokushima University, 3.Graduate School of Oral Sciences, Tokushima University)

The 95th Annual Meeting of the Japanese Biochemical Society |Thu. Nov 10, 2022 2:10 PM - 2:20 PM

[2T16a-07（1P-328）] Gene therapy and genome editing therapy for rickets type II model rats

^〇Satoko Kise¹, Kaori Yasuda¹, Tadashi Okada², Miu Nishikawa¹, Shinichi Ikushiro¹, Tomoko Nakanishi³, Izumu Saito³, Toshiyuki Sakaki¹ (1.Toyama prefectural university, 2.IRYO SOSEI UNIVERSITY, 3.Juntendo University)

The 95th Annual Meeting of the Japanese Biochemical Society |Thu. Nov 10, 2022 2:20 PM - 2:30 PM

[2T16a-08（2P-305）] A novel murine model for study on GATA1 functions in multi-step megakaryopoiesis

^〇Jia Yao¹, Ikuo Hirano^1,2, Shiho Narusawa¹, Tsz Ki Yip¹, Mikiko Suzuki^1,3, Ritsuko Shimizu^1,2 (1.Molecular Hematology, Tohoku University, 2.Tohoku Medical Megabank Organization, Tohoku University, 3.Radioisotope Center, Tohoku University)

The 95th Annual Meeting of the Japanese Biochemical Society |Thu. Nov 10, 2022 2:30 PM - 2:40 PM

[2T16a-09（2P-302）] Generation and characterization of novel trans-mitochondrial mice carrying mitochondrial tRNA^Leu(UUR) with a pathogenic mutation

^〇Haruna Tani¹, Kaori Ishikawa², Fan-Yan Wei¹, Kazuto Nakada² (1.Department of Modomics Biology and Medicine, Institute of Development, Aging and Cancer, Tohoku University, 2.Faculty of Life and Environmental Sciences, University of Tsukuba)

The 95th Annual Meeting of the Japanese Biochemical Society |Thu. Nov 10, 2022 2:40 PM - 2:50 PM

[2T17e-01（3P-280）] Evolution of carnivory in plants

^〇Naoki Arai¹, Tadahiro Ochiai², Hirofumi Doi³, Takashi Ohyama^2,4 (1.Fac. of Eng., Kanagawa Univ., 2.Grad. Sch. Adv. Sci. and Eng., Waseda Univ., 3.Hyogo Pref. Flower Ctr., 4.Dept. Biol., Fac. of Educ. and Integrated Arts and Sci., Waseda Univ.)

The 95th Annual Meeting of the Japanese Biochemical Society |Thu. Nov 10, 2022 4:40 PM - 4:50 PM

[2T17e-02（3P-282）] Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance

^〇Takayuki Ohira¹, Keiichi Minowa¹, Kei Sugiyama¹, Seisuke Yamashita², Kenjyo Miyauchi¹, Yuriko Sakaguchi¹, Ryo Noguchi¹, Akira Kaneko³, Izumi Orita³, Toshiaki Fukui³, Kozo Tomita², Tsutomu Suzuki¹ (1.Dept. Chem. Biotech., Grad. Sch. Eng., Univ. Tokyo, 2.Dept. Comp. Biol. Med. Sci., Grad. Sch. Front. Sci., Univ. Tokyo, 3.Sch. Life Sci. Tech., Tokyo Tech.)

The 95th Annual Meeting of the Japanese Biochemical Society |Thu. Nov 10, 2022 4:50 PM - 5:00 PM

[2T17e-03（1P-283）] Efficient Non-Viral Gene Transfection Method into Human Cardiac and Pulmonary Fibroblasts

^〇Makoto Matsuyama¹, Takahiro Iwamiya^1,2, Tomomi Imamura¹ (1.Metcela Inc., 2.Institute for Advanced Biosciences)

The 95th Annual Meeting of the Japanese Biochemical Society |Thu. Nov 10, 2022 5:00 PM - 5:10 PM

[2T17e-04（1P-284）] Development of a red light-responsive photoswitch (MagRed) for deep tissue optogenetics

^〇Takahiro Nakajima^1,2, Yuto Kuwasaki², Shota Yamamoto², Takahiro Otabe^1,2, Moritoshi Sato^1,2 (1.KISTEC, 2.Graduate School of Arts and Sciences, The University of Tokyo)

The 95th Annual Meeting of the Japanese Biochemical Society |Thu. Nov 10, 2022 5:10 PM - 5:20 PM