[1P-0682] Metabolic regulation in the longest-lived and tumor-resistant rodent, the naked mole rat

〇Kaori Oka¹, Yuki Oiwa¹, Yuki Sugiura², Yoji Andrew Minamishima³, Masaki Wake⁴, Norihiko Takeda⁴, Kyoko Miura¹ (1.Inst. Gen. Med., Hokkaido Univ., 2.Dept. of Biochem. and Integrative Med. Biol., Sch. of Med., Keio Univ., 3.Dept. of Mol. and Cell. Biol., Med. Inst. of Bioregulation, Kyushu Univ., 4.Dept. of Cardiovasc. Med., Grad. Sch. of Med., Univ. of Tokyo)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0683(1AS8-2)] Functional analysis of the brown adipose tissues and the beige adipose cells of the naked mole-rat, the longest-lived and non-homeothermal rodent.

〇Yuki Oiwa^1,2, Yuko Okamatsu-Ogura³, Hidemasa Bono⁴, Hideyuki Okano⁵, Kazuhiro Kimura³, Kyoko Miura¹ (1.Inst. Gen. Med., Univ. of Hokkaido, 2.Grad. Sch. of Med., Univ. of Hokkaido, 3.Grad. Sch. of Vet., Univ. of Hokkaido, 4.DBCLS, 5.Sch. of Med., Univ. of Keio)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0684] Mitochondrial dysfunction in muscle causes exercise intolerance and muscle fatigue

〇Yui Okamoto¹, Ikko Sakamoto¹, Shuichi Shibuya¹, Takahiko Shimizu¹ (1.Dept.of Clinic. Biol. and Med., Chiba Univ. Grad. Sch. of Med., Japan)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0685] The effects of partial disruption of TCA cycle on biological metabolism

〇Kanako Sumi¹, Yuiko Hatanaka¹, Kozue Shimizu¹, Ayano Naka², Kaoruko Iida³ (1.Humanities and Sciences, Ochanomizu University, 2.Human Life and Environmental Sciences, Nutrition and Food Science, Ochanomizu University, 3.Natural Science Division, Faculty of Core Research, Ochanomizu University)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0686] In vivo imaging of cytoplasmic ATP in living yeast cells suggests a survival strategy under the oxidative stress conditions

〇Masakatsu Takaine^1,2, Hiromi Imamura³, Satoshi Yoshida^1,2 (1.Gunma Univ. Ini. for Adv. Research, 2.IMCR, Gunma Univ., 3.Grad. Sch. of Biostudies, Kyoto Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0687] Cellular ATP level is reduced by general anesthetics

〇Jun-ichi Kishikawa¹, Yuki Inoue², Makoto Fujikawa³, Atsuko Nakanishi¹, Hiromi Imamura⁴, Ken Yokoyama¹ (1.Dept. Mol. Biosci., Kyoto Sangyo Univ., 2.Grad. Sch. of Biol. Sci., Nara Inst. Sci. Tech., 3.Dept. Pharrmacol. Neurobiol., Grad. Sch. of Med. Tokyo Medical and Dental Univ., 4.Grad. Sch. of Biostudies., Kyoto Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0688] Metabolic adaptation to modest OXPHOS deficiency in transgenic mice overexpressing human TFAM in muscle

Ko Igami¹, 〇Daiki Setoyama², Kazuhito Goto², Yuichi Matsushima¹, Mikako Yagi¹, Takeshi Uchiumi^1,2, Dongchon Kang^1,2 (1.Grad.Sch. of Med., CCLM, Kyushu Univ., 2.Kyushu Univ., Hosp., Clin.Lab.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0689] Metabolic function of novel anti-cancer target MTHFD2

〇Tatsunori Nishimura¹, Asuka Nakata¹, Shin-ichi Horike², Kaori Saitoh³, Keiko Kato³, Kaori Igarashi³, Susumu Kohno⁴, Chiaki Takahashi⁴, Tomoyoshi Soga³, Arinobu Tojo⁵, Noriko Gotoh^1,5 (1.Div. of Cancer Cell Biol., Cancer Res. Inst., Kanazawa Univ., 2.Div. of Functional Genomics, Advanced Sci. Res. Center, Kanazawa Univ., 3.Inst. for Advanced Biosci., Keio Univ., 4.Div. of Oncol. and Mol. Biol., Cancer Res. Inst., Kanazawa Univ., 5.Div. of Mol. Therapy, IMS, Univ. of Tokyo)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0690] An experimental approach to understand the expression mechanisms of diverse disease phenotypes in mitochondrial diseases ~Crosstalk between nucleus and mitochondria~

〇Kaori Ishikawa¹, Shun Katada², Emi Ogasawara¹, Yo Homma², Takaya Ishihara³, Takayuki Mito¹, Katsuyoshi Mihara^3,4, Jun-ichi Hayashi¹, Naotada Ishihara³, Kazuto Nakada¹ (1.Faculty of Life and Environ. Sci., Univ. of Tsukuba, 2.Grad. Sch. of Life and Environ. Sci., Univ. of Tsukuba, 3.Inst. of Life Sci., Kurume Univ., 4.Faculty of Medical Sci., Kyushu Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0691] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

〇Tetsuya Saito¹, Yoshinobu Ichimura¹, Keiko Taguchi², Takafumi Suzuki², Tsunehiro Mizushima³, Tsutomu Fujimura⁴, Takashi Ueno⁵, Tomoyuki Ohe⁶, Tadahiko Mashino⁶, Toshifumi Wakai⁷, Takayoshi Okabe⁸, Tetsuo Nagano⁸, Hozumi Motohashi⁹, Satoshi Waguri¹⁰, Tomoyoshi Soga⁶, Masayuki Yamamoto², Keiji Tanaka¹¹, Masaaki Komatsu¹ (1.Dept. of Biochem. Niigata Univ. Grad. Sch. of Med. and Dent. Sci., 2.Dept. of Med. Biochem., Tohoku Univ. Grad. Sch. of Med., 3.Univ. of Hyogo, 4.Tohoku Med. and Pharm. Univ., 5.Juntendo Univ., 6.Keio Univ., 7.Div. of Digest. and Gener. Surg. Niigata Univ. Grad. Sch. of Med. and Dent. Sci., 8.Drag Discov. Init., The Univ. of Tokyo, 9.Aging and Cancer, Tohoku Univ., 10.Fukushima Med. Univ. Sch. of Med., 11.Lab. of Protein Metab. , Tokyo Metr. Inst. of Med. Sci.)

The 39th Annual Meeting of the Molecular Biology Society of Japan