[4P-0537(3PW-02-8)] Functional analysis of mechanoresponsive Rho-GEF Solo in cell competition

〇katsuhiko kagoshima¹, Kazunari Yamashita^1,2, Kensaku Mizuno², Yasuyuki Fujita³, Kazumasa Ohasi^1,2 (1.Grad.Sch.Sci.Tohoku Univ, 2.Grad.Sch.Life.Tohoku Univ, 3.Inst. of Gen. Med.,Univ of Hokkaido)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0538] Innate immune signaling drives tumorigenesis by abrogating cell competition in Drosophila

〇Bungo Kakemura¹, Kiichiro Taniguchi¹, Tatsushi Igaki¹ (1.Div.of Sys.Lif.Sci.,Grad.Sch.of Bio.,Univ.of Kyoto.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0539] Hyaluronan synthesis inhibition enhance radiosensitivity via suppression of inflammatory signaling pathway

〇Kazuki Hasegawa¹, Ryo Saga¹, Rei Takahashi¹, Roman Fukui¹, Yoichiro Hosokawa¹ (1.Dept. of Rad. Sci., Grad. Sch. of Health. Sci., Univ. of Hirosaki)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0540] Fundamental research of the effect of cancer stem cell population modified by microenvironment of tumor mass on radiosensitivity

〇Ryo Saga¹, Kazuki Hasegawa¹, Rei Takahashi¹, Roman Fukui¹, Yoichiro Hosokawa¹ (1.Dept. of Radiat. Sci., Grad. Sch. of Health Sci., Univ. of Hirosaki)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0541] Analysis of the molecular mechanisms of the ERK-dependent cell death in various ERK-activated cancer cells induced by a novel ERK signal modulator ACA-28

〇Naoya Hamada¹, Ryosuke Satoh¹, Teruaki Takasaki¹, Genzoh Tanabe¹, Takashi Masuko¹, Reiko Sugiura¹ (1.Grad.Sch.of Pharm.,Kindai Univ.of Osaka)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0542] Catalytically activating mutation in tyrosine kinase drives oncogenicity and drug resistance, but has unique weak points

〇Ryohei Katayama¹, Koutaroh Okada^1,2, Naoya Fujita^2,3 (1.Div. Experiment. Chemother., Cancer Chemother. Ctr., JFCR, 2.Dept. of CBMS., Grad. Sch. of Front. Sci., Univ. of Tokyo, 3.Cancer Chemother. Ctr., JFCR)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0543] Development of cancer selective apoptosis inducers utilizing ERK MAPK activation

〇Ryosuke Satoh¹, Naoya Hamada¹, Fumihiro Ishikawa¹, Teruaki Takasaki¹, Genzoh Tanabe¹, Reiko Sugiura¹ (1.Fac. of Pharm., Kindai Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0544] Novel mechanism of synthetic lethality induced by SMG6 knockdown in LATS2-mutated mesothelioma cells

〇Koya Suzuki^1,2, Ryota Yamagishi³, Satomi Mukai⁵, Yoko Tabe¹, Takashi Miida¹, Hiroshi Murakami⁴, Yoshitaka Sekido⁵, Yuko Murakami-Tonami¹ (1.Dept. of Clin. Lab. Med., Grad. Sch. of Med., Juntendo Univ., 2.Res. Inst. for Dis. of Old Age, Juntendo Univ., 3.Grad. Sch. of Med., Osaka City Univ., 4.Dep. Biol. Sci., Faculty Sci. Eng., Chuo Univ., 5.Div. of Can. Biol., Aichi Canc. Cent. Res. Inst.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0545] Identification of a small compound that attenuates cancer stem cell phenotypes through regulation of BEX2.

〇Satoshi Saijoh¹, Mao Nakamura¹, Rie Shibuya¹, Takayuki Imai³, Yukinori Asada³, Kazuto Matsuura³, Mai Mochizuki¹, Kazunori Yamaguchi², Kazuo Sugamura², Jun Yasuda², Kennichi Satoh⁴, Yukio Katori⁵, Keiichi Tamai¹ (1.Division of Cancer Stem Cell , Miyagi Cancer Center Research Institute, 2.Division of Molecular and Cellular Oncology , Miyagi Cancer Center Research Institute, 3.Department of Head and Neck Surgery , Miyagi Cancer Center, 4.Division of Gastroenterology and Hepatology , Tohoku Medical and Pharmaceutical University, 5.Department of Otolaryngology-Head and Neck Surgery , Tohoku University Graduate School of Medicine)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0546] Pharmacologically targetable vulnerability in prostate adenocarcinoma carrying RB1-SUCLA2 deletion

〇Paing Linn¹, Susumu Kohno¹, Chiaki Takahashi¹ (1.Div. of Onco. & Mol. Biol., Can. Res. Inst., Kanazawa Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan