[P1-1~141] Poster Presentation 1

[P1-1] Clinical diversity in siblings with developmantal dyslexia

^○Masao Kawatani^{1, 2, 3} (1.Department of Pediatrics, University of Fukui, Fukui, Japan, 2.Child Development Research Center, University of Fukui, Fukui, Japan, 3.Hiratani Child Development Clinic, Fukui, Japan)

In developmental dyslexia (DD), it is reported that genetic factors strongly is associated in the pathogenesis. We examined the clinical similarity and difference of sibling cases diagnosed with DD. Subjects were enrolled 61 cases of 28 sibling groups diagnosed with DD using Japanese standard criteria at Hiratani child development clinic from April, 2011 to March, 2015. The age at first medical examination was earlier in older sibs than younger’s. The obvious differences during sibling groups were observed ten of 20 groups in language development, 13of 20 groups in IQ levels. The clinical diagnosis were 31 cases in autism spectrum disorder, 38 cases in attention deficit hyperactivity disorder, and 32 cases in DD (including co-existence diagnosis). There were only four sibling groups that were diagnosed of DD in both pairs, and clinical diagnosis including subcategories during sibling groups did not match in all groups except for one. In DD cases, the age at first medical examination were delayed, and language development was better than non-DD cases. Furthermore, the chief complaint in some cases of DD changed from the inappropriate communication and behavior in early childhood to the reading and writing difficulty in school ages. In this study, it was found clinical diversity in siblings with DD, and the pathogenesis of DD were varied. Therefore, we should consider the possibility of DD before entering elementary school, even if the properties were different between siblings, because of keeping up the proper diagnosis and support.