[P1-104] Clinical characteristics of six patients with status epilepticus associated with HFMD
Introduction: Hand, foot, and mouth disease (HFMD) is acute viral infection in children caused by enterovirus. Clinical symptoms are sores in mouth and eruptions on hands, feet, and sometimes buttocks. It commonly causes febrile seizure in infected children, which shows good prognosis in most cases. There were HFMD prevalence in Japan at the summer of 2015, and we encountered six patients with status epilepticus associated with HFMD.
Material&Method: Medical records were reviewed for clinical information: age, sex, past history of neurological diseases, type and time of seizures, the presence of fever and rashes at onset, laboratory data, and choice and doses of antiepileptic drugs used to treat seizures.
Results: Four male and two female patients were enrolled. The mean age was 7-months（range:11-23 ）. The mean time of seizure was 48minutes（range: 40-50 ）. The laboratory data of WBC, CRP, and serum glucose at admission were as follows; mean WBC 14400 /mm3(range:7100-21300), mean CRP 0.55mg/dl (range:0.3-1.4 ), mean serum glucose 180mg/dl (range: 87-249). In 5of 6 patients, more than 2 doses of injections of antiepileptic drug were necessary to stop seizures. In 5 of 6 patients, seizures occurred before the symptoms of fever or rashes. All patients recovered to normal. No neurological complications such as acute encephalopathy or flaccid paralysis were noted.
Conclusions: Some clinical characteristics were evident in patients with status epilepticus associated with HFMD; seizures often occur before fever or rashes, seizures were resistant to antiepileptic drug treatment, and most patients had some kind of antecedent neurological diseases.
Material&Method: Medical records were reviewed for clinical information: age, sex, past history of neurological diseases, type and time of seizures, the presence of fever and rashes at onset, laboratory data, and choice and doses of antiepileptic drugs used to treat seizures.
Results: Four male and two female patients were enrolled. The mean age was 7-months（range:11-23 ）. The mean time of seizure was 48minutes（range: 40-50 ）. The laboratory data of WBC, CRP, and serum glucose at admission were as follows; mean WBC 14400 /mm3(range:7100-21300), mean CRP 0.55mg/dl (range:0.3-1.4 ), mean serum glucose 180mg/dl (range: 87-249). In 5of 6 patients, more than 2 doses of injections of antiepileptic drug were necessary to stop seizures. In 5 of 6 patients, seizures occurred before the symptoms of fever or rashes. All patients recovered to normal. No neurological complications such as acute encephalopathy or flaccid paralysis were noted.
Conclusions: Some clinical characteristics were evident in patients with status epilepticus associated with HFMD; seizures often occur before fever or rashes, seizures were resistant to antiepileptic drug treatment, and most patients had some kind of antecedent neurological diseases.