[P1-124] Antibody Detection and Short Term Outcome of Pediatric Optic Neuritis
Optic neuritis is an inflammation of the optic nerve. In children, optic neuritis is relatively rare and the prognosis is good. We retrospectively studied two boys and seven girls (n=9) with optic neuritis who presented at the Department of Pediatrics, Nihon University Itabashi Hospital between January 1999 and November 2016. The median age at optic neuritis onset was 8 years and 4 months. Vision loss was severe in all patients, and was bilateral in four and unilateral in five. In cerebrospinal fluid, oligoclonal IgG bands were negative in all patients, although myelin basic protein was positive in three. Anti-aquaporin 4 antibody was positive in one patient, and anti-myelin oligodendrocyte glycoprotein antibody was positive in two patients. Brain magnetic resonance imaging showed swelling of the optic nerve in all patients and abnormal brain lesions in five. Four patients were diagnosed with idiopathic optic neuritis, two were diagnosed with clinically isolated syndrome, and three were diagnosed with multiple sclerosis. All patients were treated with steroid pulse therapy. Six patients with idiopathic optic neuritis and clinically isolated syndrome had full recovery of vision, no relapse, and good outcome. However, three patients with multiple sclerosis experienced relapse. Two of the three patients with multiple sclerosis had vision loss. Outcomes were good in pediatric optic neuritis with no other neurological symptoms where no antibodies were detected. However, multiple sclerosis was present in cases of optic neuritis with other neurological symptoms, and vision recovery was poor in these patients.