[P1-26] Acute encephalopathy in children: correlation of clinical type and treatment for initial seizure
[Background] There are few review for early predictor of acute encephalopathy. A predictive score for early diagnosis of AESD was purposed by Tada et al in 2015. To ascertain correlation of epidemiology, treatment for seizure, and clinical course, we examined acute severity, laboratory findings (GOT, GPT, Cr, BS), neurological sequelae, and radiological findings.
[Method] Between 2005 and 2015, 57 patients with acute encephalopathy, were enrolled in a retrospective, single center study. Acute severity was defined as patient who required mechanical ventilation or intravenous thiopental for control convulsion. Neurological sequelae were defined as PCPC score. Laboratory findings and MRI findings were also examined.
[Result] We enrolled 57 patients (28 boys) with median age of 1.0 years. Clinical type of acute encephalopathy were: 3 AESD, 3 HSE/ANE, and 36 unclassified. Etiology of acute encephalopathy were: 16 influenza virus, 5 HHV-6, 6 RS virus, 4 Rotavirus, 1 hMPV. Acute severity were 20 patients required mechanical ventilation, 5 required intravenous thiopental. Neurological sequelae were: 3 death, 9 severe, 19 mild, 24 intact, 2 unknown. Incidence of abnormal laboratory and MRI findings were more frequently in group of death or severe neurological sequelae. Similar result were obtained in acute severity.
[Conclusion] Foregoing predictors are effective in patients with acute encephalopathy, not only AESD but also in other type of acute encephalopathy.
[Method] Between 2005 and 2015, 57 patients with acute encephalopathy, were enrolled in a retrospective, single center study. Acute severity was defined as patient who required mechanical ventilation or intravenous thiopental for control convulsion. Neurological sequelae were defined as PCPC score. Laboratory findings and MRI findings were also examined.
[Result] We enrolled 57 patients (28 boys) with median age of 1.0 years. Clinical type of acute encephalopathy were: 3 AESD, 3 HSE/ANE, and 36 unclassified. Etiology of acute encephalopathy were: 16 influenza virus, 5 HHV-6, 6 RS virus, 4 Rotavirus, 1 hMPV. Acute severity were 20 patients required mechanical ventilation, 5 required intravenous thiopental. Neurological sequelae were: 3 death, 9 severe, 19 mild, 24 intact, 2 unknown. Incidence of abnormal laboratory and MRI findings were more frequently in group of death or severe neurological sequelae. Similar result were obtained in acute severity.
[Conclusion] Foregoing predictors are effective in patients with acute encephalopathy, not only AESD but also in other type of acute encephalopathy.