[P1-51] Clinical features of Benign Epilepsy of Childhood with Centrotemporal Spikes in Chinese children
[Introduction] This multicenter clinical trial was conducted to examine current practice of BECTS and especially address the question that in what circumstances one AED should be preferred.
[Methodology] 25 medical centers participate in this clinical trial. The general information, clinical information and treatment status were collected under the guidance of clinicians and then analyzed. Difference between different treatment groups were compared. And usefulness of the most commonly used AEDs were evaluated.
[Results] 1817 subjects were collected. The average age of the subject is 8.81 years old. The average age of onset is 6.85 years old (1 to 14 years). Male/Female ratio is 1.13/1. 62.9% of the patient are receiving monotherapies, and 10.6% are receiving multidrug therapy. Both age and course of disease of treated RE patients are significantly different from those of untreated patients. Bilateral findings on EEG are less seen in patients with monotherapy compared with patients with multidrug therapy. Except for 25.4% patients not taking any AEDs, Oxcarbazepine (OXC), Sodium valproate (VPA) and levetiracetam (LEV) are the most commonly used three AEDs. VPA and LEV are commonly used in add-on therapy. OXC and LEV are more effective as monotherapy than VPA.
[Conclusion]Age of onset of Chinese RE patients is 6.85 years old. Bilateral findings on EEG could be a risk factor to require multidrug therapy. in Chinese patients, Oxcarbazepine (OXC) , sodium valproate (VPA) and levetiracetam (LEV) are most commonly used AEDs as monotherapy and OXC and LEV are more effective than VPA.
[Methodology] 25 medical centers participate in this clinical trial. The general information, clinical information and treatment status were collected under the guidance of clinicians and then analyzed. Difference between different treatment groups were compared. And usefulness of the most commonly used AEDs were evaluated.
[Results] 1817 subjects were collected. The average age of the subject is 8.81 years old. The average age of onset is 6.85 years old (1 to 14 years). Male/Female ratio is 1.13/1. 62.9% of the patient are receiving monotherapies, and 10.6% are receiving multidrug therapy. Both age and course of disease of treated RE patients are significantly different from those of untreated patients. Bilateral findings on EEG are less seen in patients with monotherapy compared with patients with multidrug therapy. Except for 25.4% patients not taking any AEDs, Oxcarbazepine (OXC), Sodium valproate (VPA) and levetiracetam (LEV) are the most commonly used three AEDs. VPA and LEV are commonly used in add-on therapy. OXC and LEV are more effective as monotherapy than VPA.
[Conclusion]Age of onset of Chinese RE patients is 6.85 years old. Bilateral findings on EEG could be a risk factor to require multidrug therapy. in Chinese patients, Oxcarbazepine (OXC) , sodium valproate (VPA) and levetiracetam (LEV) are most commonly used AEDs as monotherapy and OXC and LEV are more effective than VPA.