[P2-143] The influence of corpus callosum and cerebellar on neurodevelopmental outcome of low birth weight infants
BACKGROUND: The survival rate of preterm infants was increased but these preterm survivors had higher risk for neurodevelopmental impairment than normal babies. Several factors may alter brain structure volumes and cause subsequent disability. The changes of corpus callosum or cerebellar volume have been shown to link with speech delay and motor disability. Thus, through measuring these brain structure changes, we may predict the neurological outcomes. METHOD: The cohort consisted of infants aged below 32 weeks’ gestation and with very low birth body weight (< 1500gm), who born from 2005 to 2009 and who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar area measurements were taken on cranial ultrasound at 28-30 weeks’ gestation age and at term in 13 premature with cerebral palsy (CP), 13 with mental retardation (MR) and 21 normal premature with intelligence quotient more than 85.Both MR and CP group were compared with normal group.
RESULTS:
There were significant differences between MR group and normal group in cerebellar length at 28-30wks, and MR group had reduced the genu growth between two periods. The CP group had higher incidence of cystic periventricular leukomalacia and also had smaller cerebral length and area at 28-30wks, and enlarged cerebellar area more rapidly from 28-30wks to 38-40wks.
Conclusions:
Premature baby with MR or CP had small cerebellar length at 28-30 wks gestational age. Moreover, premature with MR reduced corpus callosum growth in genu part and premature with CP rapidly enlarged cerebellar area from 28-30wks to 38-40wks gestational age.
RESULTS:
There were significant differences between MR group and normal group in cerebellar length at 28-30wks, and MR group had reduced the genu growth between two periods. The CP group had higher incidence of cystic periventricular leukomalacia and also had smaller cerebral length and area at 28-30wks, and enlarged cerebellar area more rapidly from 28-30wks to 38-40wks.
Conclusions:
Premature baby with MR or CP had small cerebellar length at 28-30 wks gestational age. Moreover, premature with MR reduced corpus callosum growth in genu part and premature with CP rapidly enlarged cerebellar area from 28-30wks to 38-40wks gestational age.