[P2-163] Clinical study of epilepsy surgery in five children with tuberous sclerosis complex
[Introduction] Tuberous sclerosis complex (TSc) is a neurocutaneous syndrome. Epilepsy appears in 60–90% of the patients with TSc, most commonly in the infantile period, and later becomes intractable. Although epilepsy surgery is one of the potential therapies. We studied the therapeutic validity and prognosis of epilepsy surgery in patients with TSc. [Method] We studied five epilepsy surgery cases of children with TSc. Their clinical data, EEG recordings, imaging data, and therapeutic courses were retrospective analyzed. [Result] Four of the 5 patients were female. The age of onset of epilepsy ranged from 2 to 18 months. Two of the patients had West syndrome in past. Three of them experienced daily seizures and the others experienced seizures on 1-6 days per week. All the patients tried 3-5 types of antiepileptic drugs. All the patients had bilateral and multiple cortical tubers. Interictal EEG revealed that while four patients had focal discharge, one had multifocal discharge. All the patients underwent video-EEG, Magnetoencephalogram (MEG), ECD-SPECT, IMZ-SPECT, FCD-PET, and Met-PET examinations before surgery. Ictal-EEG, MEG, and Met-PET were effective in determining the epileptic focus site. All the patients underwent focal resection at an age ranging from 1 to 13 years. At the time of the investigation, three patients were seizure-free and the others only experienced simple partial seizures few times a month. [Conclusion] Epilepsy surgery in patients with intractable epilepsy related to TSc is considered to be effective. Our results suggest that surgery can be considered as a therapy from an early stage.