[SP5-3C-3] The Short-Term And Long-Term Outcome Of Febrile Infection-Related Epilepsy Syndrome (Fires) In Children: One Medical Center'S Experience
[Introduction] To analyzed the outcome of FIRES in the children.
[Methods] We performed a retrospective chart review of patients with previosly normal children, who presented with status epilepticus following a nonspecific febrile illness during the period between April 2001 and October 2016 in National Taiwan University Hosipital. The functional outcome was evaluated by modified Rankin scale (mRS). Significant funtional decline was defined as the mRS difference more than 2 before hospital admission and at discharge.
[Results] We enrolled 25 patients for analysis. The age of disease onset ranged from 1.6-15.3 years(median years 9.8 years). Anesthetic agent was administered in 23 cases. The duration of the anesthetic agent ranged 3-97 days (median 27.2 days). In-hospital mortality was 20%. Newly acquired epilepsy and cognitive deficit occurred in 100% and 85%. Significant functional decline at discharge occurred in 96%. Multiple antiepileptic drugs (AEDs) (3-9 drugs)(median 6.0 drugs) were given during hospitalization. All the children were maintained on AED till the last follow-up. The number of AEDs ranged 1-6(median 3.53 AEDs). Five cases was loss follow-up. mRS for degree of disability at follow-up in short-term (<=1 year) outcome was as follows: mild(score1-2) 40%, moderate(score3-4) 60%. The long-term outcome (>=1year) was as follows: normal 46.7%, mild 26.7%, moderate 26.7%, indicating the improvement in long-term follow up.
[Conclusion] The outcome of FIRES is poor with significant mortality and morbidities. Refractory epilepsy with cognitive deficit in survive cases are common, but improvement is possible.
[Methods] We performed a retrospective chart review of patients with previosly normal children, who presented with status epilepticus following a nonspecific febrile illness during the period between April 2001 and October 2016 in National Taiwan University Hosipital. The functional outcome was evaluated by modified Rankin scale (mRS). Significant funtional decline was defined as the mRS difference more than 2 before hospital admission and at discharge.
[Results] We enrolled 25 patients for analysis. The age of disease onset ranged from 1.6-15.3 years(median years 9.8 years). Anesthetic agent was administered in 23 cases. The duration of the anesthetic agent ranged 3-97 days (median 27.2 days). In-hospital mortality was 20%. Newly acquired epilepsy and cognitive deficit occurred in 100% and 85%. Significant functional decline at discharge occurred in 96%. Multiple antiepileptic drugs (AEDs) (3-9 drugs)(median 6.0 drugs) were given during hospitalization. All the children were maintained on AED till the last follow-up. The number of AEDs ranged 1-6(median 3.53 AEDs). Five cases was loss follow-up. mRS for degree of disability at follow-up in short-term (<=1 year) outcome was as follows: mild(score1-2) 40%, moderate(score3-4) 60%. The long-term outcome (>=1year) was as follows: normal 46.7%, mild 26.7%, moderate 26.7%, indicating the improvement in long-term follow up.
[Conclusion] The outcome of FIRES is poor with significant mortality and morbidities. Refractory epilepsy with cognitive deficit in survive cases are common, but improvement is possible.