[P3-3pm] 16. Natural Products Chemistry, Chemical Biology

[P3-3pm-07] Synthesis and Na_VCh-inhibitory activity assay of saxitoxin derivatives with a tertiary alcohol and a side chain at C11

^○Kako Maeno¹, Ayato Nureki¹, Yuka Takayanagi¹, Hayate Ishizuka¹, Osamu Chiba², Shutaro Yoshio², Takumi Kobayashi², Takatsugu Hirokawa³, Keiichi Konoki², Mari Yamashita², Kazuo Nagasawa¹ (1. Graduate School of Engineering, Tokyo University of Agriculture and technology, 2. Graduate School of Agricultural Science, Tohoku University, 3. Division of Biomedical Science, University of Tsukuba)

[Lang.] Japanese

Keywords:saxitoxin, guanidine alkaloid, voltage-gated sodium channel, structure-activity relationship